Future strategies for acute cardioprotection: ‘melatonin as promising therapy’

Abreu-González, Pedro

doi:10.1093/cvr/cvx136

Cited by 5 publications

(9 citation statements)

References 3 publications

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“…In addition, it appears that other promising effects such as anti-apoptotic, anti-inflammatory [ 127 ], preconditioning [ 118 , 128 ], myocardial infarction [ 129 , 130 , 131 ], and even an implication in heart failure [ 132 , 133 , 134 , 135 ] have been documented. However, it seems than in some conditions, melatonin can have deleterious effects, as exaggerated collagen and glycosaminoglycans deposition and increased size in post-myocardial infarction scar have also been reported [ 136 , 137 ]. A reduction in cardiovascular risk factors such as diabetes and hyperlipidemia could be of use in preventive cardiovascular care.…”

Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

“…Despite numerous clinical and preclinical trials, authors with vast experience in the field of ischemia/reperfusion injury, preconditioning, and cardioprotection do not believe melatonin to be relevant to MI scar reduction in STEMI reperfused patients [ 137 ].…”

Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

“…Although very promising in preclinical trials, melatonin seems to fail to deliver clinically. Melatonin failed the translational trial in established cardiovascular disease [ 137 ], but nevertheless acts on several cardiovascular disease risk factors (diabetes, obesity, hypertension, dyslipidemia). Should this be a clue it ought to be included in the prevention guidelines for patients at risk of developing cardiovascular diseases?…”

Section: Promising Clinical Targets and Pending Questionsmentioning

confidence: 99%

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Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

et al. 2020

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There is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits. The anti-inflammatory and antioxidant effects of melatonin are intertwined and are exerted throughout pregnancy and later during development and aging. Melatonin supplementation during pregnancy can reduce ischemia-induced oxidative damage in the fetal brain, increase offspring survival in inflammatory states, and reduce blood pressure in the adult offspring. In adulthood, disturbances in melatonin production negatively impact the progression of cardiovascular risk factors and promote cardiovascular and neurodegenerative diseases. The most studied cardiovascular effects of melatonin are linked to hypertension and myocardial ischemia/reperfusion injury, while the most promising ones are linked to regaining control of metabolic syndrome components. In addition, there might be an emerging role for melatonin as an adjuvant in treating coronavirus disease 2019 (COVID 19). The present review summarizes and comments on important data regarding the roles exerted by melatonin in homeostasis and oxidative stress and inflammation related pathologies.

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Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

Section: Promising Clinical Targets and Pending Questionsmentioning

confidence: 99%

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Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

et al. 2020

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“…Because of MT's involvement in the regulating of inflammatory processes, carbon and lipid metabolism, its application is effective for prophylactic treatment of atherosclerosis, ischemic brain injury, cerebrovascular diseases, etc. [169][170][171]. MT had a beneficial effect on reducing ROS production and protecting of pancreatic beta cells in patients with diabetes mellitus [172].…”

Section: Melatonin As a Neuroimmunoendocrine Marker And Molecular Tar...mentioning

confidence: 99%

Melatonin as the Cornerstone of Neuroimmunoendocrinology

Kvetnoy

Ivanov

Mironova

et al. 2022

IJMS

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Much attention has been recently drawn to studying melatonin – a hormone whose synthesis was first found in the epiphysis (pineal gland). This interest can be due to discovering the role of melatonin in numerous physiological processes. It was the discovery of melatonin synthesis in endocrine organs (pineal gland), neural structures (Purkinje cells in the cerebellum, retinal photoreceptors), and immunocompetent cells (T lymphocytes, NK cells, mast cells) that triggered the evolution of new approaches to the unifield signal regulation of homeostasis, which, at the turn of the 21st century, lead to the creation of a new integral biomedical discipline—neuroimmunoendocrinology. While numerous hormones have been verified over the last decade outside the “classical” locations of their formation, melatonin occupies an exclusive position with regard to the diversity of locations where it is synthesized and secreted. This review provides an overview and discussion of the major data regarding the role of melatonin in various physiological and pathological processes, which affords grounds for considering melatonin as the “cornerstone” on which neuroimmunoendocrinology has been built as an integral concept of homeostasis regulation.

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“…Melatonin is reportedly involved in the regulation of the cardiovascular system by influencing smooth muscle tone and arterial pressure [2, 3]. Accumulating evidence shows that impaired melatonin production is involved in several cardiovascular pathologies [4] including hypertension [5, 6], ischemic heart disease [7–9], heart failure [10], and myocardial infarction [11].…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise enhanced endothelium-dependent vasorelaxation in mesenteric arteries in spontaneously hypertensive rats: the role of melatonin

et al. 2018

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Melatonin, a neuroendocrine hormone synthesized primarily by the pineal gland, provides various cardiovascular benefits. Regular physical activity is an effective non-pharmacological therapy for the prevention and control of hypertension. In the present study, we hypothesized that melatonin plays an important role in the aerobic exercise-induced increase of endothelium-dependent vasorelaxation in the mesenteric arteries (MAs) of spontaneously hypertensive rats (SHRs) in a melatonergic receptor-dependent manner. To test this hypothesis, we evaluated the vascular mechanical and functional properties in normotensive Wistar Kyoto (WKY), SHRs, and SHRs that were trained on a treadmill (SHR-EX) for 8 weeks. Exercise training produced a significant reduction in blood pressure and heart rate in SHR, which was significantly attenuated by the intraperitoneal administration of luzindole, a non-selective melatonin receptor (MT1/MT2) antagonist. Serum melatonin levels in the SHR group were significantly lower than those in the WKY group at 8:00-9:00 and 21:00-22:00, while exercise training reduced this difference. Endothelium-dependent vessel relaxation induced by acetylcholine was significantly blunted in SHR compared with age-matched WKY. Both exercise training and luzindole ameliorated this endothelium-dependent impairment of relaxation in hypertension. Immunohistochemistry and Western blotting showed that the protein expression of the MT2 receptor and eNOS, as well as their colocalization in the endothelial cell layer in SHRs, was significantly decreased; as exercise training suppressed this reduction. These results provide evidence that regular exercise has a beneficial effect on improving endothelium-dependent vasorelaxation in MAs, in which melatonin plays a critical role by acting on MT2 receptors to increase NO production and/or NO bioavailability.

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Future strategies for acute cardioprotection: ‘melatonin as promising therapy’

Cited by 5 publications

References 3 publications

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

Melatonin as the Cornerstone of Neuroimmunoendocrinology

Aerobic exercise enhanced endothelium-dependent vasorelaxation in mesenteric arteries in spontaneously hypertensive rats: the role of melatonin

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