“Future role of [18F]-FDG PET/CT in patients with bladder cancer in the new era of neoadjuvant immunotherapy?”

Utility of Routine Preoperative 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computerized Tomography in Identifying Pathological Lymph Node Metastases at Radical Cystectomy. Letter.

“…In the context of immunotherapy, Marandino et al recently reported that [ 18 F]-FDG PET/CT would have prevented 7% of patients with non-enlarged lymph nodes (<8 mm) from inappropriately receiving neoadjuvant pembrolizumab. 11,12 Some results support the idea that interpretation criteria in [ 18 F]-FDG PET/CT should be adjusted according to the size of the nodes. 13 While a mild uptake can lead to classifying enlarged lymph nodes as cN+, strong uptake should be required for small ones to avoid false positives.…”