2015
DOI: 10.1164/rccm.201505-0963ws
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Future Research Directions in Asthma. An NHLBI Working Group Report

Abstract: Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the NHLBI convened a group of extramural investigators for an Asthma Research Strategic Planning workshop on September 18-19, 2014, to accelerate discoveries and their translation to patients. The work… Show more

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Cited by 85 publications
(55 citation statements)
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“…4,5 Young children are particularly diverse with numerous and variable phenotypic presentations in early life that correspond to different outcomes, 6-9 yet they are incompletely studied and significant treatment gaps remain. 10,11 Even among young children who warrant treatment with daily inhaled corticosteroids (ICS) , the response to ICS is inconsistent, 12 perhaps due to differences in symptom presentation and/or persistence 13 or other underlying inflammatory features.…”
Section: Introductionmentioning
confidence: 99%
“…4,5 Young children are particularly diverse with numerous and variable phenotypic presentations in early life that correspond to different outcomes, 6-9 yet they are incompletely studied and significant treatment gaps remain. 10,11 Even among young children who warrant treatment with daily inhaled corticosteroids (ICS) , the response to ICS is inconsistent, 12 perhaps due to differences in symptom presentation and/or persistence 13 or other underlying inflammatory features.…”
Section: Introductionmentioning
confidence: 99%
“…Traditional asthma therapies, although effective for many patients, provide only temporary symptomatic alleviation [103]. Moreover, even with these interventions, some patients still experience exacerbations and progressive deterioration of pulmonary function [5, 12].…”
Section: Resultsmentioning
confidence: 99%
“…Layer in the global interest in personalized medicine and existing asthma clinical network efforts to categorize specific asthma populations based on their underlying pathology (Levy, et al, 2015), and it is not difficult to envision an expanded repertoire of asthma drugs, or drug combinations tailored to better manage specific asthmatic subpopulations. Perhaps most encouraging (for the treatment of all diseases) is the promise of biased ligand pharmacology, which now has a strong foundation built on multiple basic science disciplines and will likely find wide spread clinical application once industry expands its platforms and strategies to accommodate the reality that ligands have much greater capacity to manipulate GPCRs than previously thought.…”
Section: What We Can Expect In the Near (And Not-so-near) Futurementioning
confidence: 99%