Future Pharmacotherapies for Male Lower Urinary Tract Symptoms

Novel intraprostatic injectable agents in the treatment of BPH

“…One concern regarding prostatic ethanol ablation is the difficulty in controlling distribution and the potential risk of bladder necrosis due to inadvertent injection [14,15] . Use of anhydrous ethanol in a gel formulation has been described as a potential solution to this problem.…”

“…This is thought to be secondary to dissipation of the injected ethanol. Major complications such as widespread bladder necrosis leading to cystectomy has led to ethanol ablation being abandoned as a viable therapeutic option [6,10,14] .…”