2021
DOI: 10.1080/03007995.2021.1978960
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Future perspective: metabolism as a therapeutic target in acute myeloid leukemia – from Warburg to precision medicine

Abstract: Acute myeloid leukemia (AML) is a highly malignant blood cancer disease, with dismal prognosis.The theory that cancer cells utilize metabolism to their growth advantage was postulated almost hundred years ago. However, only recently have been able to take advantage of this Achilles heel of malignant cell growth. Current observations suggest a crucial role for various metabolic pathways in AML, and special in leukemia stem cells (LSC), believed to be responsible for re-initiation of the leukemic clone, and henc… Show more

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