Future of the Particle Replication in Nonwetting Templates (PRINT) Technology

Xu, Jing; Wong, Dominica H. C.; Byrne, James D.; Chen, Kai; Bowerman, Charles J.; DeSimone, Joseph M.

doi:10.1002/anie.201209145

Cited by 175 publications

(123 citation statements)

References 79 publications

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“…[22] The gelation reaction was carried out in micromolds with a homogeneous dimethyl sulfoxide (DMSO) solution of NIPAm monomer, crosslinker (N,N′-methylene-bisacrylamide), photoinitiator, and gold nanorods (GNR). The maximum of the longitudinal plasmon absorption was at 791 nm.…”

mentioning

confidence: 99%

Soft Microrobots Employing Nonequilibrium Actuation via Plasmonic Heating

et al. 2016

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A soft microrobot composed of a microgel and driven by the light‐controlled nonequilibrium dynamics of volume changes is presented. The photothermal response of the microgel, containing plasmonic gold nanorods, enables fast heating/cooling dynamics. Mastering the nonequilibrium response provides control of the complex motion, which goes beyond what has been so far reported for hydrophilic microgels.

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confidence: 99%

Soft Microrobots Employing Nonequilibrium Actuation via Plasmonic Heating

et al. 2016

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“…W hile Nature routinely constructs complex biological structures with exquisite control, laboratory-based synthetic methods are only beginning to reach similar levels of precision in the creation of nanoscale architectures [1][2][3][4][5][6][7] . Advances in the preparation of soft matter nanostructures have recently made possible the preparation of a wide variety of objects with well-defined dimensions and hierarchies.…”

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confidence: 99%

Colour-tunable fluorescent multiblock micelles

et al. 2014

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Emerging strategies based on the self-assembly of block copolymers have recently enabled the bottom-up fabrication of nanostructured materials with spatially distinct functional regions. Concurrently, a drive for further miniaturization in applications such as optics, electronics and diagnostic technology has led to intense interest in nanomaterials with well-defined patterns of emission colour. Using a series of fluorescent block copolymers and the crystallization-driven living self-assembly approach, we herein describe the synthesis of multicompartment micelles in which the emission of each segment can be controlled to produce colours throughout the visible spectrum. This represents a bottom-up synthetic route to objects analogous to nanoscale pixels, into which complex patterns may be written. Because of their small size and high density of encoded information, these findings could lead to the development of new materials for applications in, for example, biological diagnostics, miniaturized display technology and the preparation of encoded nanomaterials with high data density.

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“…In PRINT technology, an elastomeric mold containing wells or cavities of predefined shape and size is utilized to fabricate particles with precise structures. 23,24 The biopharmaceutical cargo such as proteins can be incorporated in PRINT particles by encapsulation or adsorption. For example, Hemagglutinin (HA) antigens in three commercial trivalent influenza vaccine (TIV), were electrostatically bound to the surface of cylindrical cationic PLGA-based NPs prepared by PRINT technology.…”

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confidence: 99%

Peptide/protein vaccine delivery system based on PLGA particles

Allahyari

Mohit

2015

Human Vaccines & Immunotherapeutics

173

109

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Due to the excellent safety profile of poly (D,L-lactide-co-glycolide) (PLGA) particles in human, and their biodegradability, many studies have focused on the application of PLGA particles as a controlled-release vaccine delivery system. Antigenic proteins/peptides can be encapsulated into or adsorbed to the surface of PLGA particles. The gradual release of loaded antigens from PLGA particles is necessary for the induction of efficient immunity. Various factors can influence protein release rates from PLGA particles, which can be defined intrinsic features of the polymer, particle characteristics as well as protein and environmental related factors. The use of PLGA particles encapsulating antigens of different diseases such as hepatitis B, tuberculosis, chlamydia, malaria, leishmania, toxoplasma and allergy antigens will be described herein. The co-delivery of antigens and immunostimulants (IS) with PLGA particles can prevent the systemic adverse effects of immunopotentiators and activate both dendritic cells (DCs) and natural killer (NKs) cells, consequently enhancing the therapeutic efficacy of antigen-loaded PLGA particles. We will review co-delivery of different TLR ligands with antigens in various models, highlighting the specific strengths and weaknesses of the system. Strategies to enhance the immunotherapeutic effect of DCbased vaccine using PLGA particles can be designed to target DCs by functionalized PLGA particle encapsulating siRNAs of suppressive gene, and disease specific antigens. Finally, specific examples of cellular targeting where decorating the surface of PLGA particles target orally administrated vaccine to Mcells will be highlighted.

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Future of the Particle Replication in Nonwetting Templates (PRINT) Technology

Cited by 175 publications

References 79 publications

Soft Microrobots Employing Nonequilibrium Actuation via Plasmonic Heating

Soft Microrobots Employing Nonequilibrium Actuation via Plasmonic Heating

Colour-tunable fluorescent multiblock micelles

Peptide/protein vaccine delivery system based on PLGA particles

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