Future of preventing and managing common chronic inflammatory diseases

Abstract

Chronic inflammation has emerged as a key factor that contributes to some common chronic diseases and reduces lifespan. Studies have identified multiple types of chronic inflammation ranging from autoimmune disease, which attacks specific tissues, to autoinflammatory diseases, which cause low-grade systemic inflammation and contribute to several common chronic diseases. This article highlights new perspectives on the role of chronic inflammation in cardiovascular disease (CVD). Such information is being leveraged to develop new treatment strategies for CVD and may inform how periodontal disease influences CVD.

Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era

“…Poor oral health and comorbidities are common among them [59] , which makes them especially vulnerable against COVID-19 [60] . The evidence supports that the systemic inflammation connects periodontitis to several chronic diseases of aging [10] . Furthermore, hospitalized patients are more likely to suffer from nosocomial pneumonia if they have periodontitis [61] .…”

“…Oral health seems to be one part of the puzzles. Periodontitis is associated with several underlying health conditions that are also considered as risk factors for severe COVID-19 disease [4] , [5] , [6] , [7] , [8] , [9] , [10] , [54] . Therefore, next to the typical recommendations of social distancing and respiratory, hand, and surface hygiene from the official health organizations, targeted prevention of periodontal disease among COVID-19 risk groups based on individual oral health risk seems important and becomes even more important as the epidemic may last longer than expected.…”

“…If the point-of-care test is positive indicating a risk of active periodontal disease, patients should be referred to a dentist for periodontal examination and evaluation. Systemic inflammation links periodontitis to several other chronic inflammatory diseases, such as diabetes, CVD and Alzheimer’s disease, and can alter their course [4] , [5] , [6] , [7] , [8] , [9] , [10] , [64] . Previous studies also indicate the positive effect of periodontal therapy on systemic markers of inflammation [65] .…”

“…Periodontitis is a chronic multifactorial infectious and inflammatory disease that not only leads to the destruction of tooth supporting tissues but can also have adverse systemic effects [3] . Mounting evidence in the literature suggests that periodontitis as a chronic low-burden inflammation is associated with several chronic systemic diseases, including diabetes, cardiovascular diseases (CVD), chronic obstructive pulmonary disease (COPD), hypertension, and cancer [4] , [5] , [6] , [7] , [8] , [9] , [10] . These same systemic diseases, as well as old age, have been identified as risk factors for severe COVID-19 infections [11] , [12] .…”

Experimental testing of tannic acid target delivery system for correcting periodontal microcirculation

“…The Centers for Disease Control and Prevention consistently report a high prevalence of various forms of periodontitis among 47% of people aged 30 and over. Periodontal disease is accompanied by systemic inflammation associated with many chronic diseases [1]. Recent advances in nanotechnology allowed developing new therapeutic materials for treating periodontitis [2,3].…”