Future of Insect Repellents

Debboun, Mustapha; Frances, Stephen P.; Strickman, Daniel

doi:10.1201/b17407-26

Cited by 27 publications

(41 citation statements)

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“…Natural sources, such as local herbs and gum, oil and plant-based smoke, have been used by mankind for millennia as mosquito repellents and are still utilized today by 50-90% of residents throughout the rural tropics [1]. Intensive research to discover more effective, long-lasting, and water-resistant repellents began during WWII because of more than one million cases of malaria recorded among the U.S. troops involved in overseas campaigns [1].…”

Section: Introductionmentioning

confidence: 99%

“…Intensive research to discover more effective, long-lasting, and water-resistant repellents began during WWII because of more than one million cases of malaria recorded among the U.S. troops involved in overseas campaigns [1]. The most effective wide-spectrum synthetic repellent to emerge from this program was N,N-diethyl-3-methylbenzamide (DEET) (see Figure 1) discovered in 1952.…”

Section: Introductionmentioning

confidence: 99%

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Promising Aedes aegypti Repellent Chemotypes Identified through Integrated QSAR, Virtual Screening, Synthesis, and Bioassay

Oliferenko

Poda

et al. 2013

PLoS ONE

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Molecular field topology analysis, scaffold hopping, and molecular docking were used as complementary computational tools for the design of repellents for Aedes aegypti, the insect vector for yellow fever, chikungunya, and dengue fever. A large number of analogues were evaluated by virtual screening with Glide molecular docking software. This produced several dozen hits that were either synthesized or procured from commercial sources. Analysis of these compounds by a repellent bioassay resulted in a few highly active chemicals (in terms of minimum effective dosage) as viable candidates for further hit-to-lead and lead optimization effort.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Promising Aedes aegypti Repellent Chemotypes Identified through Integrated QSAR, Virtual Screening, Synthesis, and Bioassay

Oliferenko

Poda

et al. 2013

PLoS ONE

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“…The fact that all powder treatments produced PR values of > 70% is a welcome scientific development based on the promise it holds for the rationalised use of botanical pesticides for long-term protection of stored durable agricultural products, such as maize grains, against the LGB and other storedproduct insect pests. The observed repellent activity could partly be attributed to the presence of volatile constituents such as monoterpenes and sesquiterpenes which are well-known repellents of phytophagous (biting) insects by acting in the vapour form on the olfactory receptors (Moore & Lenglet 2004;Debboun et al 2007;Wang et al 2008). The results from this study showed clearly that botanicals exhibited contact-repellent properties against P. truncatus and that the test insects made oriented movements away from treated grains to get acceptable food as manifested in the alternate treated-untreated bioassay system (Dethier et al 1960).…”

Section: Repellence Studies (Choice Bioassay)mentioning

confidence: 99%

Bioactivity of selected plant powders against Prostephanus truncatus (Coleoptera: Bostrichidae) in stored maize grains

Chebet¹,

Deng²,

Ogendo³

et al. 2013

Plant Prot. Sci.

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“…Repellent or biocidal compounds are often formulated in a spray or body skin lotion to act against harmful arthropod species which mainly belong to the taxa Diptera and Acari [10,11]. To the best of our knowledge, no publication describes the testing of a skin lotion against wasps in the field.…”

Section: Discussionmentioning

confidence: 99%

“…, the jam), which is the usual method of testing repellency. Moreover, there is also no clear-cut limit between repellency (by olfaction) and deterrence (gustation) caused by “volatile” compounds [10,13]. Hence, it is unlikely that the mix of skin lotion and jam confounded the results.…”

Section: Discussionmentioning

confidence: 99%

Field Method for Testing Repellency of an Icaridin-Containing Skin Lotion against Vespid Wasps

Boevé

Eertmans

Adriaens³

et al. 2016

Insects

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Vespid wasps are ecologically beneficial predators of insects but their stings also pose a human health risk. Current control methods based on killing vespids are suboptimal. Here, the repellent effect against Vespula vulgaris of a 20% icaridin skin lotion was evaluated under field conditions. An experimental setup was designed in which six artificial skin pieces (10 × 10 cm) were video-recorded for 1 h, to count each min the numbers of flying and feeding vespids. Prior to monitoring, five pieces were successively smeared with 2 mg of cream per cm2, in 30 min intervals, from t = −120 min to 0. The sixth sheet remained untreated to serve as a control. One milliliter of an attractant, fruit jam, was deposited on each of the six surfaces at t = 0. The control surface was free of any flying or feeding vespid during an average period of 25 min, whereas the other five surfaces (treated at t = −120, −90, −60, −30, and 0 min) remained vespid-free for 39, 40, 45, 49, and 51 min, respectively. The skin lotion remained significantly active for at least 2 h. The experimental methodology is adjustable and allows the study of repellents against vespids in semi-natural conditions.

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Future of Insect Repellents

Cited by 27 publications

References 0 publications

Promising Aedes aegypti Repellent Chemotypes Identified through Integrated QSAR, Virtual Screening, Synthesis, and Bioassay

Promising Aedes aegypti Repellent Chemotypes Identified through Integrated QSAR, Virtual Screening, Synthesis, and Bioassay

Bioactivity of selected plant powders against Prostephanus truncatus (Coleoptera: Bostrichidae) in stored maize grains

Field Method for Testing Repellency of an Icaridin-Containing Skin Lotion against Vespid Wasps

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