Future of Helicobacter pylori and its feasibility

Abadi, Amin Talebi Bezmin; Kusters, Johannes G.

doi:10.1080/14787210.2018.1523715

Cited by 2 publications

(2 citation statements)

References 25 publications

(25 reference statements)

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“…[10–14] However, other studies hold the opposite views on the efficiency and safety of probiotics in assisting with the eradication. [15–17] Although some previous studies was focused on the probitic addition, the timing and duration of probiotic addition remain unclear. [18–21] Therefore, we performed a meta-analysis of the most recent and most favorable evidence to evaluate the efficacy and safety, and explore the optimal timing and duration of probiotics in assisting with the eradication of H pylori .…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of probiotics in eradicating Helicobacter pylori

Shi

Zhang

et al. 2019

Medicine

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Background: Due to decreasing eradication rate and increasing side effects, probiotics have gradually become an important supplement to standard eradication regimens for Helicobacter pylori . Objective: To evaluate the effectiveness and safety of probiotics in facilitating the eradication of H pylori and to explore the best timing and duration of probiotic supplementation, use of eradication regimens, strains, locations, and common side effects. Methods: Eligible studies were retrieved from the PubMed, EMBASE, Cochrane Library, Web of Science, and CNKI databases, and we applied the Stata 12.0 software for the standard meta-analysis and network meta-analysis. Results: Forty eligible studies with 8924 patients were included in the analysis. We used a random-effects model ( I 2 = 52.1% and I 2 = 81.4%) to analyze the eradication rate and the incidence of total side effects by intention to treat (ITT). Compared with the control group, a higher eradication rate (relative risk [RR] 1.140, 95% confidence interval (CI) 1.101–1.180, P < .001) and lower incidence of total side effects (RR 0.470, 95% CI 0.391–0.565, P < .001) were observed in the probiotic group. In the subgroup analysis, we evaluated the surface under the cumulative ranking curve scores for the before + same (75.2%), >2 weeks (92.6%), probiotic + quadruple regimen (99.9%), Lactobacillus (73.6%), multiple strains (72.1%), China (98.5%) groups. The rankings of common side effects are shown in Table 6. SUCRA scores for diarrhea (39.7%), abdominal pain (43.9%), nausea (78.8%), taste disturbance (99.6%), vomiting (7.1%), and constipation (30.9%) were reported. The consistency of all comparison groups was good. Conclusions: Probiotics improved the eradication rate and reduced side effects when added to the treatments designed to eradicate H pylori . The use of probiotics before the eradication treatment and throughout the eradication treatment, and also the use of probiotics for more than 2 weeks, exerted better eradication effects. Probiotics combined with the bismuth quadruple regimen was the best combination. Lactobacillus and multiple strains were better choices of probiotic strains. The eradication effect observed in China was better than the effect observed in other countries.

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Section: Introductionmentioning

confidence: 99%

Efficacy and safety of probiotics in eradicating Helicobacter pylori

Shi

Zhang

et al. 2019

Medicine

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“…Similarly, the meta-analysis of Dang et al revealed no significant effect of probiotics on the eradication rate regardless if they were used alone or combined with standard antibiotic regimens [ 81 ]. Other studies also support the fact that probiotics prove no efficacy and safety in assisting with the eradication [ 100 , 101 ] ( Table 2 ). Therefore, the results reported in the literature remain controversial and require further studies in order to clearly delineate the impact of probiotics on the H. pylori eradication rate.…”

Section: Antibiotics Versus Probiotics In Pediatric H Pylor...mentioning

confidence: 80%

The Challenges of Eradicating Pediatric Helicobacter pylori Infection in the Era of Probiotics

2022

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Helicobacter pylori (H. pylori), the most common infection of childhood, results in life-threatening complications during adulthood if left untreated. Most of these complications are related to H. pylori-induced chronic inflammation. The dysbiosis caused by H. pylori is not limited to the gastric microenvironment, but it affects the entire gastrointestinal tract. Eradication of H. pylori has recently become a real challenge for clinicians due to both the persistent increase in antibiotic resistance worldwide and the wide spectrum of side effects associated with the eradication regimens resulting; therefore, there is an urgent need for more effective and less noxious treatment options. Thus, probiotics might be a promising choice in both adults and children with H. pylori infection since their role in improving the eradication rate of this infection has been proved in multiple studies. The positive effects of probiotics might be explained by their abilities to produce antimicrobial compounds and antioxidants, alter local gastric pH, and subsequently decrease H. pylori colonization and adherence to gastric epithelial cells. Nevertheless, if used alone probiotics do not considerably increase the eradication rate.

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Future of Helicobacter pylori and its feasibility

Cited by 2 publications

References 25 publications

Efficacy and safety of probiotics in eradicating Helicobacter pylori

Efficacy and safety of probiotics in eradicating Helicobacter pylori

The Challenges of Eradicating Pediatric Helicobacter pylori Infection in the Era of Probiotics

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