Future of chemoprophylaxis as a measure for the practical control of poliomyelitis

Re: Alexander TH, Davidson TM. Intranasal zinc and anosmia: the zinc‐induced anosmia syndrome. Laryngoscope 2006;116:217–220.

“…Seidman appears to be unaware of the extensive literature and acceptance by the scientific community of the loss of smell resulting from intranasal zinc ions. Zinc olfactory toxicity was extensively reported by Schultz in the 1930s and standardized for rodent work in 1971 by Alberts 2–4 . Slotnick tabulated almost 90 publications regarding zinc olfactory toxicity in a variety of animal experiments, including such diverse species as turtles, goats, hamsters, catfish, monkeys, and humans (“Table.…”

A Simple Method for Developing Olfactory Discrimination Habits in Rats

“…Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. The use of zinc sulphate to immunize monkeys and man against poliomeyelitis has been found to produce temporary anosmia in the majority of subjects if properly administered (3,4). It is generally believed that this substance modifies the olfactory filaments with which it comes into contact in the olfactory epithelium and that its effectiveness as an immunizing agent may actually be dependent upon their destruction.…”