Future Drug Treatments for Type 1 Diabetes

Biocatalyzed synthesis of antidiabetic drugs: A review

“…For sure, the improvement of metabolic pathways for increasing their production can be classified as sequential (or cascade) biocatalytical processes, and not many examples of protease modifications of precursors leading to insulin analogues, which can be sensu stricto considered biotransformations, can be found in literature (Bogsnes et al 2003;Habermann and Zocher 2008). Anyway, ample research is being carried out in the development of new analogues of insulin (Freeland and Farber 2016;Pettus et al 2016;Zaykov et al 2016;Sherr et al 2017) and new and faster formulations (Sherr et al 2017), because there is little to no alternatives to brand-named analogue insulin and non-analogue human alternatives for treating both types of DM in low-and middle-income countries (Kaplan and Beall 2017).…”