Future directions of extracellular vesicle-associated miRNAs in metastasis

López, Jesús Adrián; Granados-López, Angélica Judith

doi:10.21037/atm.2017.01.26

Cited by 3 publications

(2 citation statements)

References 64 publications

(60 reference statements)

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“…The two most powerful serum-based signatures identified here, sja-miR-2b-5p and sja-miR-2c-5p, were listed as the top fourth and fourteenth miRNAs associated with S. japonicum adult EVs (Zhu et al ., 2016 a ), indicating that serum and serum-exosomal miRNAomes are significantly different in terms of miRNA numbers, types and expression profiles (Zhao et al ., 2016). Although accumulating evidence indicates that extracellular miRNAs are mainly found bound to AGO proteins (Lopez and Granados-Lopez, 2017), an active sorting mechanism of exosomal miRNA may enrich specific miRNA members in extracellular vesicles/exosomes (Villarroya-Beltri et al ., 2013; Janas et al ., 2015; Zhang et al ., 2015; Gon et al ., 2017). Further detection of parasite-derived miRNAs from serum EV composition represents another direction for the diagnosis of human S. japonicum infection.…”

Section: Discussionmentioning

confidence: 99%

Parasite-derived circulating microRNAs as biomarkers for the detection of human Schistosoma japonicum infection

Cai

Olveda

et al. 2019

Parasitology

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Novel tools for early diagnosis and monitoring of schistosomiasis are urgently needed. This study aimed to validate parasite-derived miRNAs as potential novel biomarkers for the detection of human Schistosoma japonicum infection. A total of 21 miRNAs were initially validated by real-time-polymerase chain reaction (RT-PCR) using serum samples of S. japonicum-infected BALB/c mice. Of these, 6 miRNAs were further validated with a human cohort of individuals from a schistosomiasis-endemic area of the Philippines. RT-PCR analysis showed that two parasite-derived miRNAs (sja-miR-2b-5p and sja-miR-2c-5p) could detect infected individuals with low infection intensity with moderate sensitivity/specificity values of 66%/68% and 55%/80%, respectively. Analysis of the combined data for the two parasite miRNAs revealed a specificity of 77.4% and a sensitivity of 60.0% with an area under the curve (AUC) value of 0.6906 (P = 0.0069); however, a duplex RT-PCR targeting both sja-miR-2b-5p and sja-miR-2c-5p did not result in an increased diagnostic performance compared with the singleplex assays. Furthermore, the serum level of sja-miR-2c-5p correlated significantly with faecal egg counts, whereas the other five miRNAs did not. Targeting S. japonicum-derived miRNAs in serum resulted in a moderate diagnostic performance when applied to a low schistosome infection intensity setting.

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Section: Discussionmentioning

confidence: 99%

Parasite-derived circulating microRNAs as biomarkers for the detection of human Schistosoma japonicum infection

Cai

Olveda

et al. 2019

Parasitology

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“…The composition of the AT is not limited only to adipocytes. A variety of cell types such as immune cells, endothelial cells, fibroblasts, among others, are interconnected, sharing soluble mediators like adipokines, miRNAs, among others, with autocrine/paracrine action, in order to participate collectively in metabolic homeostasis [25,26], adipogenesis, lipogenesis, and lipolysis [27,28].…”

Section: Adipogenesis Linked To Cancer Developmentmentioning

confidence: 99%

miRNAs as Interconnectors between Obesity and Cancer

González-Sánchez,

Granados-López,

López-Hernández

et al. 2024

ncRNA

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Obesity and cancer are a concern of global interest. It is proven that obesity may trigger the development or progression of some types of cancer; however, the connection by non-coding RNAs has not been totally explored. In the present review, we discuss miRNAs and lncRNAs dysregulation involved in obesity and some cancers, shedding light on how these conditions may exacerbate one another through the dysregulation of ncRNAs. lncRNAs have been reported as regulating microRNAs. An in silico investigation of lncRNA and miRNA interplay is presented. Our investigation revealed 44 upregulated and 49 downregulated lncRNAs in obesity and cancer, respectively. miR-375, miR-494-3p, miR-1908, and miR-196 were found interacting with 1, 4, 4 and 4 lncRNAs, respectively, which are involved in PPARγ cell signaling regulation. Additionally, miR-130 was found to be downregulated in obesity and reported as modulating 5 lncRNAs controlling PPARγ cell signaling. Similarly, miR-128-3p and miR-143 were found to be downregulated in obesity and cancer, interacting with 5 and 4 lncRNAs, respectively, associated with MAPK cell signaling modulation. The delicate balance between miRNA and lncRNA expression emerges as a critical determinant in the development of obesity-associated cancers, presenting these molecules as promising biomarkers. However, additional and deeper studies are needed to reach solid conclusions about obesity and cancer connection by ncRNAs.

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The Emerging Roles of microRNAs in Stem Cell Aging

Dietrich

Singh

Kumar

et al. 2018

Advances in Experimental Medicine and Biology

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Aging is the continuous loss of tissue and organ function over time. MicroRNAs (miRNAs) are thought to play a vital role in this process. miRNAs are endogenous small noncoding RNAs that control the expression of target mRNA. They are involved in many biological processes such as developmental timing, differentiation, cell death, stem cell proliferation and differentiation, immune response, aging and cancer. Accumulating studies in recent years suggest that miRNAs play crucial roles in stem cell division and differentiation. In the present chapter, we present a brief overview of these studies and discuss their contributions toward our understanding of the importance of miRNAs in normal and aged stem cell function in various model systems.

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Future directions of extracellular vesicle-associated miRNAs in metastasis

Cited by 3 publications

References 64 publications

Parasite-derived circulating microRNAs as biomarkers for the detection of human Schistosoma japonicum infection

Parasite-derived circulating microRNAs as biomarkers for the detection of human Schistosoma japonicum infection

miRNAs as Interconnectors between Obesity and Cancer

The Emerging Roles of microRNAs in Stem Cell Aging

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