Future directions in endometriosis research

D’Hooghe, Thomas; Debrock, Sophie; Meuleman, Christel; Hill, Joseph A.; Mwenda, Jason M.

doi:10.1016/s0889-8545(02)00063-3

Cited by 51 publications

(52 citation statements)

References 127 publications

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“…The variety of symptoms, signs and locations and the difficulty in establishing the diagnosis of the disease are the main difficulties in estimating the prevalence of the disease [5]. Extrapelvic endometriosis has many histologic patterns varying from typical endometrial glands to an abundance of fibrous tissue [6]. …”

Section: Introductionmentioning

confidence: 99%

Thoracic Endometriosis Syndrome

Augoulea

Lambrinoudaki²,

Christodoulakos³

2007

Respiration

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Endometriosis is defined as the presence of endometrial glands and stroma outside the uterine cavity and is usually confined to the pelvis. Thoracic endometriosis syndrome (TES) is a rare disorder characterized by the presence of functioning endometrial tissue in the pleura, the lung parenchyma and the airways. TES may present with hemoptysis, due to the shedding of endometrial tissue in the bronchial tree, or spontaneous pneumothorax or hemothorax if the endometrial tissue is localized peripherally. Patients are of reproductive age, often nulliparous, with long-standing symptoms. The crucial issue for establishing the diagnosis is the cyclicity of the symptoms which occur along with the menstrual cycle. TES is virtually a diagnosis of exclusion, established on clinical grounds, since neither CT nor endoscopy are specific for TES. Treatment consists of gonadotropin-releasing hormone analogues, aiming to suppress the hypophyseal-gonadal axis, so as to ensure a regression of the endometrial implants. If medical treatment fails, surgical resection of the endometriomas is suggested, although relapse rate may be high.

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Section: Introductionmentioning

confidence: 99%

Thoracic Endometriosis Syndrome

Augoulea

Lambrinoudaki²,

Christodoulakos³

2007

Respiration

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“…Numerous endometriosis-associated immunological changes were detected in the eutopic endometrium and the peripheral blood (Giudice et al 1998, Giudice 2003, D'Hooghe et al 2004, Sharpe-Timms 2005, but were particularly observed locally in the peritoneal cavity where the disease often develops.…”

Section: Introductionmentioning

confidence: 99%

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Lawson

Al-Akoum

Maheux³

et al. 2007

Reproduction

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The establishment and progression of ectopic endometrial implants are dependent upon their interaction with and responsiveness to the stimuli present in their new environment. According to our and other previous studies, immune cells-derived cytokines, such as IL-1, may alone or in concert with estrogens, enhance the capability of ectopic endometrial cells to implant and develop into the host tissue. In the present study, immunohistochemical and dual immunofluorescence analyses showed that the functional signaling interleukin-1 receptor type 1 (IL-1RI) is expressed in endometriotic tissue, particularly in the glands, and identified endothelial cells, macrophages, and T-lymphocytes as cells having marked expression of IL-1RI. The highest concentrations of IL-1RI protein in endometriotic tissue, as evaluated using histological score (HSCORE) and measured by ELISA, were found in red endometriotic lesions as compared with typical black-blue or white lesions. Western blotting showed a significant increase in the levels of the 50 kDa band, whose apparent molecular weight corresponds to the soluble form of IL-1RI. RT-PCR analysis of IL-1 mRNA levels showed a pattern of expression comparable to that of the protein. Interestingly, IL-1RI expression was more significant in the proliferative than in the secretory phase of the menstrual cycle. Marked expression of IL-1RI, the functional signaling receptor that mediates cell activation by IL-1, in red endometriotic implants, which are highly vascularized and represent the earliest and most active forms of the disease, point to a higher cell receptivity for IL-1 in these lesions, a relationship with the activity of the disease and a possible involvement in the early steps of endometriotic tissue growth and development. Reproduction (2007) 133 265-274

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“…The WHO definition of 2009 defines infertility as an absence of pregnancy for at least 12 months [19], thus this population was classified as infertile. The median age at surgery was 31,5 years [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], median BMI 23,4 (17,7-31,1), median preoperative parity was 0 [0-1],and gravidity was 0 [0-3] Table 2.…”

Section: Patientsmentioning

confidence: 99%

“…Further research should be conducted to understand the physiological mechanisms of endometriosis and the concomitant effects on fertility. Results of such research will eventually lead to an approach other than surgical intervention or medical treatment with GnRH agonists [23].…”

Section: Patientsmentioning

confidence: 99%

Outcome of Fertility after Radical Conservative Surgery in Grade III-IV Endometriosis Lesions: A Retrospective Analysis

Baekelandt¹,

Arne²,

Aelvoet³

et al. 2016

Int J Gynecol Clin Pract

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Purpose: Researching reproductive outcome after laparoscopic radical resection of grade III and IV endometrial lesions. Methods and Materials: A retrospective analysis of 54 women was carried out. The patients underwent laparoscopic radical resection in the Gynecology Department of a secondary health care center between January 2009 and December 2013. Diagnostic investigation, with histological confirmation of moderate to severe endometriosis, preceded surgical intervention in a multidisciplinary setting. Thirty seven of the 54 patients had an active desire for pregnancy. The outcome measure was the number of pregnancies in the subgroup of 37 women with an active desire for pregnancy. Results: Within the subgroup of 37 patients, 28 women became pregnant within the study period. Twelve patients became pregnant spontaneously and 16 had medically assisted pregnancies. Within the medically assisted group, 4 patients conceived after Intra-Uterine Insemination (IUI) and 12 after InVitro Fertilization (IVF). The pregnancy rate was 76%, a result similar to findings of earlier studies. Conclusion:The results of this retrospective analysis suggest that extensive laparoscopic surgery for moderate to severe endometriosis has a beneficial effect on fertility in both spontaneous and medically assisted pregnancies.

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Future directions in endometriosis research

Cited by 51 publications

References 127 publications

Thoracic Endometriosis Syndrome

Thoracic Endometriosis Syndrome

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Outcome of Fertility after Radical Conservative Surgery in Grade III-IV Endometriosis Lesions: A Retrospective Analysis

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