Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

Wainwright, Cherry L.; Teixeira, Mauro Martins; Adelson, David L.; Buenz, Eric J.; David, Bruno; Glaser, Keith B.; Harata-Lee, Yuka; Howes, M.-J.R.; Izzo, Angelo A.; Maffia, Pasquale; Mayer, Alejandro M. S.; Mazars, Claire; Newman, David J.; Lughadha, Eimear Nic; Pimenta, A. M. C.; Parra, J. C.; Qu, Zhibo; Shen, Hao; Spedding, Michael; Wolfender, JL

doi:10.1016/j.phrs.2022.106076

Cited by 43 publications

(32 citation statements)

References 408 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that natural products can modulate immunomodulatory action, targeting important modulators of inflammation such as TNF-α, IL-1β, and nitric oxide (NO) production, indicating a potential avenue for new anti-inflammatory agents. 24 A mixture of plant esterified sterols (with ferulic appendages and triterpene alcohols, collectively known as γ-oryzanol, has been reported to display such unique properties. This mixture has shown potent antioxidant activity and can modulate lipid metabolism in a H 2 O 2 human hepatic L02 cell model.…”

Section: Impact Of Ros On Human Healthmentioning

confidence: 99%

“…Furthermore, the levels of interleukin (IL) cell signaling proteins (IL-4, IL-5, and IL-13) were significantly reduced by treatment with 16 in a similar pattern to the dexamethasone-treated group of animal models. 24 These cytokines regulate the inflammatory response in order to clear foreign entities by changing the abundance of various cell populations through binding to their corresponding cellular receptors. The combined studies indicate the betulin compounds might be complementary to current anti-inflammatory treatments.…”

Section: Impact Of Ros On Human Healthmentioning

confidence: 99%

See 1 more Smart Citation

Triterpenoids as Reactive Oxygen Species Modulators of Cell Fate

Ling¹,

Boyd²,

Rivas³

2022

Chem. Res. Toxicol.

View full text Add to dashboard Cite

The triterpenoid natural products have played an important role in understanding mechanistic models of human diseases. These natural products are diverse, but many have been characterized as reactive oxygen species (ROS) modulators. ROS can regulate cell survival and function, which ultimately affects biological processes leading to disease. The triterpenoids offer an untapped source of creativity to generate tool compounds with high selectivity to regulate ROS. This brief Review highlights the diverse complexity by which these secondary metabolites induce many cell death modalities (apoptosis, autophagy, ferroptosis, etc.) that can affect various complex cell signaling pathways through ROS and ultimately lead to evading or accelerating cell death.

show abstract

Section: Impact Of Ros On Human Healthmentioning

confidence: 99%

Section: Impact Of Ros On Human Healthmentioning

confidence: 99%

Triterpenoids as Reactive Oxygen Species Modulators of Cell Fate

Ling¹,

Boyd²,

Rivas³

2022

Chem. Res. Toxicol.

View full text Add to dashboard Cite

show abstract

“…Aβ is produced as a predictable consequence of these physiological modifications ( Tariq et al, 2021 ). Numerous botanical herbs demonstrated anti-amyloidogenic properties, indicating its influences on the accumulation and instability of pre-existing Aβ fibrillary aggregates in the CNS ( Maccioni et al, 2010 ; Mir et al, 2021b ; Nomoto et al, 2021 ; Wainwright et al, 2022 ). Aside from the medicinal herbs listed, studies have investigated the anti-amyloidogenic properties of ellagic acids, garlic acid, dry ginger extract, isolates of mulberry leaf, and caper buds, which are all consumable dietary elements ( Fujiwara et al, 2006 , 2009 ; Papandreou et al, 2006 ).…”

Section: Anti-amyloid Effectsmentioning

confidence: 99%

Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders

et al. 2022

View full text Add to dashboard Cite

The current scientific community is facing a daunting challenge to unravel reliable natural compounds with realistic potential to treat neurological disorders such as Alzheimer’s disease (AD). The reported compounds/drugs mostly synthetic deemed the reliability and therapeutic potential largely due to their complexity and off-target issues. The natural products from nutraceutical compounds emerge as viable preventive therapeutics to fill the huge gap in treating neurological disorders. Considering that Alzheimer’s disease is a multifactorial disease, natural compounds offer the advantage of a multitarget approach, tagging different molecular sites in the human brain, as compared with the single-target activity of most of the drugs so far used to treat Alzheimer’s disease. A wide range of plant extracts and phytochemicals reported to possess the therapeutic potential to Alzheimer’s disease includes curcumin, resveratrol, epigallocatechin-3-gallate, morin, delphinidins, quercetin, luteolin, oleocanthal, and other phytochemicals such as huperzine A, limonoids, and azaphilones. Reported targets of these natural compounds include inhibition of acetylcholinesterase, amyloid senile plaques, oxidation products, inflammatory pathways, specific brain receptors, etc. We tenaciously aimed to review the in-depth potential of natural products and their therapeutic applications against Alzheimer’s disease, with a special focus on a diversity of medicinal plants and phytocompounds and their mechanism of action against Alzheimer’s disease pathologies. We strongly believe that the medicinal plants and phytoconstituents alone or in combination with other compounds would be effective treatments against Alzheimer’s disease with lesser side effects as compared to currently available treatments.

show abstract

“…Currently, there is an effort to find bioactive compounds from NPs as starting points for the further development of drug candidates for infectious diseases: antibacterial [ 12 ], antiprotozoal [ 13 ], antifungal [ 14 ], and antiviral [ 15 ]. Additionally, NPs are currently employed in medicinal chemistry to develop new chemotherapies, for example, neurodegenerative [ 16 ], cancer [ 17 ], immune-related [ 18 ], liver [ 19 ], and kidney [ 20 ] diseases, to mention a few examples. Moreover, during the current pandemic outbreak, NPs have been a rich source for discovering potential lead compounds against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Progress and Impact of Latin American Natural Product Databases

Gómez-García

Medina-Franco

2022

Biomolecules

View full text Add to dashboard Cite

Natural products (NPs) are a rich source of structurally novel molecules, and the chemical space they encompass is far from being fully explored. Over history, NPs have represented a significant source of bioactive molecules and have served as a source of inspiration for developing many drugs on the market. On the other hand, computer-aided drug design (CADD) has contributed to drug discovery research, mitigating costs and time. In this sense, compound databases represent a fundamental element of CADD. This work reviews the progress toward developing compound databases of natural origin, and it surveys computational methods, emphasizing chemoinformatic approaches to profile natural product databases. Furthermore, it reviews the present state of the art in developing Latin American NP databases and their practical applications to the drug discovery area.

show abstract

Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

Cited by 43 publications

References 408 publications

Triterpenoids as Reactive Oxygen Species Modulators of Cell Fate

Triterpenoids as Reactive Oxygen Species Modulators of Cell Fate

Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders

Progress and Impact of Latin American Natural Product Databases

Contact Info

Product

Resources

About