Future directions for epidemiology in epilepsy

Linehan, Christine; Téllez‐Zenteno, José F.; Burneo, Jorge G.; Berg, Anne T.

doi:10.1016/j.yebeh.2011.06.006

Cited by 21 publications

(20 citation statements)

References 51 publications

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“…This is a limitation because our results cannot be compared with previous and future studies which using ICD-10 or Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) to define mental disorders. In order to improve upon the methodology used in this study, future studies may consider applying a population-based omnibus survey to better reflect epilepsy in the general population [53].…”

Section: Discussionmentioning

confidence: 99%

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

Chang

Liao

et al. 2013

PLoS ONE

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BackgroundPsychiatric manifestations after occurrence of epilepsy have often been noted. However, the association between newly diagnosed epilepsy and psychiatric disorders afterward is not completely understood. We conducted two longitudinal cohorts for patients with and without epilepsy to investigate the risk factors and hazard ratios of developing psychiatric disorders after patients were newly diagnosed with epilepsy.MethodsWe identified 938 patients with a new diagnosis of epilepsy and 518,748 participants without epilepsy from the National Health Insurance Research Database in 2000–2002 and tracked them until 2008. We compared the incidence of developing psychiatric disorders between the two cohorts, evaluated risk factors and measured the associated hazard ratios (HRs) and 95% confidence intervals (CIs) of developing psychiatric disorders.FindingsThe incidences of psychiatric disorders for people with and without epilepsy were 94.1 and 22.6 per 1000 person-years, respectively. After adjusting the covariates, the epilepsy cohort showed the highest risks in mental retardation (HR 31.5, 95% CI 18.9 to 52.4), bipolar disorder (HR 23.5, 95% CI 11.4 to 48.3) and alcohol or drug psychosis (HR 18.8, 95% CI 11.1 to 31.8) among psychiatric complications developed after newly diagnosed epilepsy. The risk increased with epileptic general seizure and frequency of outpatient visits for epilepsy, as well as with emergency room visits and hospitalizations for epilepsy, and with older age. Chronologically, the highest risk occurred in the first year after epilepsy diagnosis (HR 11.4, 95% CI 9.88 to 13.2).ConclusionVarious psychiatric disorders were demonstrated after newly diagnosed epilepsy and closely related to general seizure and use of medical services for epilepsy. This shows a need for integrated psychiatric care for patients newly diagnosed with epilepsy, especially in the first year.

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Section: Discussionmentioning

confidence: 99%

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

Chang

Liao

et al. 2013

PLoS ONE

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“…While it is not disputed that there are high rates of NCC-epilepsy comorbidity in certain developing countries [16], determining the existence, or non-existence, of a causal relationship between epilepsy and NCC is far more complex. Considering the nature of the interactions that exist between these two conditions, a number of hypotheses can be considered.…”

Section: Introductionmentioning

confidence: 99%

The causal relationship between neurocysticercosis infection and the development of epilepsy - a systematic review

Gripper

Welburn

2017

Infect Dis Poverty

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BackgroundNeurocysticercosis (NCC) is a parasitic infection of the human central nervous system, the most common form of which involves infection of the brain parenchyma with the larval form of the Taenia solium tapeworm. A causal relationship between such an NCC infection and the development of epilepsy in infected individuals is acknowledged, in part supported by high levels of comorbidity in endemic countries worldwide.MethodsThis study undertook a systematic review and critical analysis of the NCC-epilepsy relationship with the primary objective of quantifying the risk of developing epilepsy following NCC infection. A secondary aim was to analyse the proportions of NCC-associated epilepsy within different populations. Significant emphasis was placed on the importance of neuroimaging (CT or MRI) availability and use of clear guidelines for epilepsy diagnosis, in order to avoid overestimations of prevalence rates of either condition; a limitation identified in several previous studies.ResultsA common odds ratio of 2.76 was identified from meta-analysis of case-control studies, indicating that an individual infected with NCC has almost a three times higher risk of developing epilepsy than an uninfected individual. Furthermore, meta-analysis of studies identified a common proportion of 31.54% of epilepsy cases associated with NCC infection which suggests that amongst epileptic populations in at risk countries, approximately one-third may be associated with NCC infection.ConclusionA significant finding was the lack of good clinical data to enable accurate determination of a causal relationship. Even studies that were included had noticeable limitations, including a general lack of consistency in diagnostics, and lack of accurate epidemiological data. This review highlights a need for consistency in research in this field. In the absence of reliable estimates of its global burden, NCC will remain of low priority in the eyes of funding agencies - a truly neglected disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-017-0245-y) contains supplementary material, which is available to authorized users.

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“…Epidemiology continues to be an important research tool in the study of epilepsy and related disorders, providing a better understanding of the frequency, causes, and natural history of the disorder. 3 …”

Section: Introductionmentioning

confidence: 99%

Spectrum of epilepsy – prevalence, impact, and treatment gap: an epidemiological study from Al-Quseir, Egypt

El-Tallawy¹,

Farghaly²,

Rageh³

et al. 2016

NDT

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BackgroundEpidemiology continues to be an important research tool in the study of epilepsy and related disorders, providing a better understanding of the frequency, causes, and natural history of the disorder.ObjectiveTo estimate the prevalence of epilepsy in Al-Quseir, Red Sea Governorate, Egypt, and its magnitude of treatment gap.MethodsThe study was part of a door-to-door study, including every door, to screen all inhabitants in Al-Quseir (33,818 inhabitants) by three specialists of neurology and 15 female social workers (for demographic data collection) using a standardized screening questionnaire. All suspected cases were subjected to detailed history, clinical examination, and electroencephalogram. Neuroimaging studies and estimation of serum drug level were done in select cases if needed.ResultsThe study revealed that the lifetime prevalence rate of epilepsy in Al-Quseir is 5.5/1,000, with the highest peak during early childhood, while that of active epilepsy is 3.3/1,000 population. The annual incidence rate is 48/100,000, and the age-specific incidence rate has a U-shaped pattern with two peaks of incidence in early infancy and elderly life. Localization-related epilepsy is the most frequently encountered type (58.8%). The treatment gap of epilepsy in Al-Quseir is 83.8%.ConclusionThe lifetime prevalence of epilepsy in Al-Quseir city, Red Sea Governorate, was 5.5/1000.

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Future directions for epidemiology in epilepsy

Cited by 21 publications

References 51 publications

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

The causal relationship between neurocysticercosis infection and the development of epilepsy - a systematic review

Spectrum of epilepsy – prevalence, impact, and treatment gap: an epidemiological study from Al-Quseir, Egypt

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Future directions for epidemiology in epilepsy

Cited by 21 publications

References 51 publications

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

The causal relationship between neurocysticercosis infection and the development of epilepsy - a systematic review

Spectrum of epilepsy &ndash; prevalence, impact, and treatment gap: an epidemiological study from Al-Quseir, Egypt

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Spectrum of epilepsy – prevalence, impact, and treatment gap: an epidemiological study from Al-Quseir, Egypt