Future Biomarkers for Infection and Inflammation in Rheumatoid Arthritis

Cui, Shuang; Qian, Jie

doi:10.2147/jir.s413579

Cited by 3 publications

(2 citation statements)

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“… 36 Also, the positive correlation between lipocalin-2 CRP and ESR is attributed to the fact that they are considered important inflammatory indicators, and their production is stimulated by pro-inflammatory cytokines that play an important role in causing arthritis. 12 , 37 Lipocalin-2 promotes neutrophils to release pro-inflammatory cytokines such as interleukins, tumor necrosis factor (TNF-α), and nuclear factor kappa B (NF-kB) proteins are activated as well as LCN2 levels have been associated with an increased inflammatory environment of bone. Consequently, serious illnesses may result from neutrophil malfunction.…”

Section: Discussionmentioning

confidence: 99%

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Lipocalin-2 as a marker of inflammation, bone density, and triglyceride-glucose index for new-onset arthritis patients in Mosul, Iraq

Saadon,

Allwsh

2024

Qatar Medical Journal

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Objective: Lipocalin-2 is an acute phase-associated adipokine that can serve as an inflammatory and biomarker indicator of cartilage deterioration in osteoarthritis. However, its role in the musculoskeletal system remains not fully understood. Hence, this study aimed to evaluate lipocalin-2 and its relationship with markers of inflammation (Interferon-gamma, ESR, and CRP), bone density (vitamin D3 and calcium), and the triglyceride-glucose index in new-onset arthritis patients in Mosul, Iraq. Methods: This study included 125 participants aged 20 to 65, divided into two groups. The Arthritis Patient Group comprised 70 participants (37 females and 33 males) attending the Bone Diseases Consultation Unit at the Ibn Sina Teaching Hospital in Mosul, Iraq. The Control Group comprised 31 females and 24 males. Ethical approval was obtained from the Iraqi Ministry of Health - Nineveh Health (No. 2022095). Commercial ELISA kits were used to measure serum lipocalin-2, Interferon-gamma, ESR, and CRP as inflammation markers, vitamin D3, and calcium as bone density markers. Moreover, the Triglyceride Glucose (TYG) Index was evaluated. Results: The findings revealed a significant increase in lipocalin-2 levels in males compared to females, with LCN-2 increasing with age. Arthritis patients showed a significant increase (72%) in lipocalin-2 levels. Inflammatory indicators (erythrocyte sedimentation rate, C-reactive protein, interferon-gamma) displayed significant increases (46%, 1200%, and 581%, respectively). Glucose (23%), triglycerides (71%), and TYG index (21%) also exhibited significant increases. Meanwhile, bone density indicators (vitamin D3 and calcium) found a significant decrease (53% and 20%, respectively) in arthritis patients. Linear correlation coefficient (R) analysis revealed a significant positive relationship between lipocalin-2 and indicators of inflammation, glucose, TG, and TYG index. Conclusion: This study’s findings suggest that LCN-2 serum levels were higher in patients with new-onset arthritis than in controls in Mosul, and LCN-2 serum increased in males compared with females and getting older serum LCN-2 increased for the patients and control groups. Furthermore, a significant correlation was found between the Triglyceride Glucose Index, which measures metabolic disorders, and serum LCN-2 levels and inflammatory indicators in new-onset arthritis patients in Mosul, Iraq.

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Section: Discussionmentioning

confidence: 99%

“…CRP is also an immune regulator that has an important function in pathways of inflammation associated with atherogenic. 12 …”

Section: Introductionmentioning

confidence: 99%

Lipocalin-2 as a marker of inflammation, bone density, and triglyceride-glucose index for new-onset arthritis patients in Mosul, Iraq

Saadon,

Allwsh

2024

Qatar Medical Journal

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The potential role of serum amyloid A as biomarker of rheumatic diseases: a systematic review and meta-analysis

Zinellu,

Mangoni

2024

Clin Exp Med

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The identification of novel, robust biomarkers for the diagnosis of rheumatic diseases (RDs) and the presence of active disease might facilitate early treatment and the achievement of favourable long-term outcomes. We conducted a systematic review and meta-analysis of studies investigating the acute phase reactant, serum amyloid A (SAA), in RD patients and healthy controls to appraise its potential as diagnostic biomarker. We searched PubMed, Scopus, and Web of Science from inception to 10 April 2024 for relevant studies. We evaluated the risk of bias and the certainty of evidence using the JBI Critical Appraisal Checklist and GRADE, respectively (PROSPERO registration number: CRD42024537418). In 32 studies selected for analysis, SAA concentrations were significantly higher in RD patients compared to controls (SMD = 1.61, 95% CI 1.24–1.98, p < 0.001) and in RD patients with active disease compared to those in remission (SMD = 2.17, 95% CI 1.21–3.13, p < 0.001). Summary receiving characteristics curve analysis showed a good diagnostic accuracy of SAA for the presence of RDs (area under the curve = 0.81, 95% CI 0.78–0.84). The effect size of the differences in SAA concentrations between RD patients and controls was significantly associated with sex, body mass index, type of RD, and study country. Pending the conduct of prospective studies in different types of RDs, the results of this systematic review and meta-analysis suggest that SAA is a promising biomarker for the diagnosis of RDs and active disease.

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Distorted frequency and functionality of natural killer cells in pemphigus vulgaris: A potential therapeutic target

Hooda,

Khandpur,

Arava

et al. 2024

Immunology Letters

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Future Biomarkers for Infection and Inflammation in Rheumatoid Arthritis

Cited by 3 publications

References 57 publications

Lipocalin-2 as a marker of inflammation, bone density, and triglyceride-glucose index for new-onset arthritis patients in Mosul, Iraq

Lipocalin-2 as a marker of inflammation, bone density, and triglyceride-glucose index for new-onset arthritis patients in Mosul, Iraq

The potential role of serum amyloid A as biomarker of rheumatic diseases: a systematic review and meta-analysis

Distorted frequency and functionality of natural killer cells in pemphigus vulgaris: A potential therapeutic target

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