Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer

Gao, Yaqi; Zou, Tian-Hui; Xu, Pingping; Wang, Yingchao; Jiang, Yi; Chen, Yingxuan; Chen, Haoyan; Hong, Jie; Fang, Jing‐Yuan

doi:10.1016/j.neo.2022.100850

Cited by 22 publications

(16 citation statements)

References 39 publications

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“…In addition, METTL3 mediated m6A modification of YPEL5 mRNA and inhibited YPEL5 expression in a YTHDF2-dependent manner, which promoted the proliferation, migration, and metastasis of CRC (33). METTL3 can also enhance the expression of IFIT1 in a way dependent m6A-IGF2BP2/3, resulting in fusobacterium nucleatum-induced PD-L1 upregulation and cell proliferation in CRC (36). Functionally, METTL3 knockdown drastically inhibited CRC stemness in vitro and suppressed CRC growth and metastasis in cell-based and PDX-based subcutaneous tumor models.…”

Section: Effects Of Mettl3 On Crcmentioning

confidence: 99%

m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

et al. 2023

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N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism, including translocation, mRNA stability or decay, pre-mRNA splicing, and lncRNA processing. Numerous studies have shown that m6A modification is involved in the development of various cancers. This review aims to summarize the significant role of m6A modification in the proliferation and tumorigenesis of CRC, as well as the potential of modulating m6A modification for tumor treatment. These findings may offer new therapeutic strategies for clinical implementation of m6A modification in CRC in the near future.

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Section: Effects Of Mettl3 On Crcmentioning

confidence: 99%

m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

et al. 2023

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“… 101 , 102 Additionally, other biological behaviors of CRC, including proliferative and invasive abilities, can also be enhanced by F. nucleatum . 38 , 103 In the future, further clinical trials targeting the microbes within breast cancer should be designed and conducted, which may reduce breast cancer metastasis.…”

Section: Contributions Of Microbes From Different Dimensions In Cance...mentioning

confidence: 99%

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Zhao

Mei

et al. 2023

Sig Transduct Target Ther

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In the past period, due to the rapid development of next-generation sequencing technology, accumulating evidence has clarified the complex role of the human microbiota in the development of cancer and the therapeutic response. More importantly, available evidence seems to indicate that modulating the composition of the gut microbiota to improve the efficacy of anti-cancer drugs may be feasible. However, intricate complexities exist, and a deep and comprehensive understanding of how the human microbiota interacts with cancer is critical to realize its full potential in cancer treatment. The purpose of this review is to summarize the initial clues on molecular mechanisms regarding the mutual effects between the gut microbiota and cancer development, and to highlight the relationship between gut microbes and the efficacy of immunotherapy, chemotherapy, radiation therapy and cancer surgery, which may provide insights into the formulation of individualized therapeutic strategies for cancer management. In addition, the current and emerging microbial interventions for cancer therapy as well as their clinical applications are summarized. Although many challenges remain for now, the great importance and full potential of the gut microbiota cannot be overstated for the development of individualized anti-cancer strategies, and it is necessary to explore a holistic approach that incorporates microbial modulation therapy in cancer.

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“…The increased expression of PD-L1 in CRC cells both in vitro and in vivo is a mechanism involved in the influence of certain pathogenic bacteria associated with an immunosuppressive TME[ 96 ]. In contrast, bacteria associated with healthy microbiota improve the efficacy of anti-PD-L1 therapy by enhancing the accumulation of cytotoxic T cells in the TME[ 97 ].…”

Section: Established Dynamics Between the Gut Microbiota The Tme And ...mentioning

confidence: 99%

How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells

Díaz¹,

Carriere²,

Gentili³

2023

World J Stem Cells

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Colorectal cancer (CRC) remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant characteristics. It is well established that the appearance of distal metastasis in CRC patients is the cause of a poor prognosis and treatment failure. Nevertheless, in the last decades, CRC aggressiveness and progression have been attributed to a specific cell population called CRC stem cells (CCSC) with features like tumor initiation capacity, self-renewal capacity, and acquired multidrug resistance. Emerging data highlight the concept of this cell subtype as a plastic entity that has a dynamic status and can be originated from different types of cells through genetic and epigenetic changes. These alterations are modulated by complex and dynamic crosstalk with environmental factors by paracrine signaling. It is known that in the tumor niche, different cell types, structures, and biomolecules coexist and interact with cancer cells favoring cancer growth and development. Together, these components constitute the tumor microenvironment (TME). Most recently, researchers have also deepened the influence of the complex variety of microorganisms that inhabit the intestinal mucosa, collectively known as gut microbiota, on CRC. Both TME and microorganisms participate in inflammatory processes that can drive the initiation and evolution of CRC. Since in the last decade, crucial advances have been made concerning to the synergistic interaction among the TME and gut microorganisms that condition the identity of CCSC, the data exposed in this review could provide valuable insights into the biology of CRC and the development of new targeted therapies.

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Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer

Cited by 22 publications

References 39 publications

m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells

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