Fusobacterium nucleatum Endocarditis Presenting as Liver and Brain Abscesses in an Immunocompetent Patient

Dahya, Vishal; Patel, Jaymin; Wheeler, Mark; Ketsela, Gizatchew

doi:10.1097/maj.0000000000000388

Cited by 20 publications

(17 citation statements)

References 6 publications

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“…In our review of literature, we identified only 12 cases of F. nucleatum monomicrobial PLA in immunocompetent cancer-free hosts in the English literature (table 1). 3 5 8–17 Only one of those patients was diabetic. Four patients (33.3%) had a single abscess with the remainder of cases having multiple hepatic abscess.…”

Section: Discussionmentioning

confidence: 99%

Concurrent fusobacterial pyogenic liver abscess and empyema

2019

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We present a very rare case of concurrent empyema and liver abscess caused by Fusobacterium. Our patient presented with 3-month history of subtle abdominal discomfort and cough leading to eventually presenting with marked chest pain, dyspnoea and septic shock. CT revealed a liver abscess and large right-sided pleural effusion. Drainage of the pleural effusion yielded gross pus with the growth of Fusobacterium varium, while drainage of the liver abscess yielded Fusobacterium nucleatum. The patient responded to drainage and antibiotic therapy with resolution of symptoms and decrease in the size of empyema and abscess on follow-up imaging. We also include a review if literature of related fusobacterial infections.

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Section: Discussionmentioning

confidence: 99%

Concurrent fusobacterial pyogenic liver abscess and empyema

2019

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“…Fusobacteirum nucleatum es una bacteria que se ha asociado fuertemente con el establecimiento y mantenimiento de la biopelícula oral por la capacidad de promover la coagregación bacteriana, que finalmente termina generando múltiples enfermedades en cavidad oral como la periodontitis (Flanagan et al, 2014;Dahya et al, 2015;Budd et al, 2015). Su tratamiento ha estado marcado por medicamentos de orígen sintético como la clorhexidina, el cual ha logrado efectos bactericidas sobre periodontopatógenos y biopelícula oral, reflejados en disminución de la inflamación, enrojecimiento y bolsa periodontal.…”

Section: Discussionunclassified

Efecto antimicrobiano del aceite esencial de Citrus reticulata sobre Fusobacterium nucleatum asociada a enfermedad periodontal

C¹,

Monsalve²,

Erira³

et al. 2017

Rev. colomb. biotecnol.

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Efecto antimicrobiano aceite esencial de Citrus reticulata 7 Efecto antimicrobiano del aceite esencial de Citrus reticulata sobre Fusobacterium nucleatum asociada a enfermedad periodontal Antimicrobial effect of essential oil of Citrus reticulata on Fusobacterium nucleatum associated with periodontal disease RESUMEN La clorhexidina como tratamiento de la enfermedad periodontal ha logrado efectos bactericidas sobre periodontopatógenos y biopelícula oral. Su uso genera efectos adversos, por lo tanto se presentan alternativas naturales con efecto antimicrobiano similar. Los aceites esenciales han demostrado efectividad en el control de la placa dental, sin los efectos adversos de la clorhexidina. El objetivo de este estudio fue determinar el efecto bacteriostático y bactericida del aceite esencial de mandarina contra Fusobacterium nucleatum. Se realizó extracción por expresión del aceite esencial de cáscaras de mandarina (variedades Arrayana y Oneco). Se evaluaron concentraciones al 20%, 40%, 60%, 80% y 100% del aceite esencial diluido en Tween al 0,02%. El efecto bacteriostático y bactericida se determinó por pruebas de sensibilidad antimicrobiana por difusión en disco. Como control positivo se utilizó Clorhexidina 0,2% y agua como control negativo. Se midió halo de inhibición (mm) y se determinó ausencia o presencia de crecimiento bacteriano a partir de unidades formadoras de colonias. Para comparación de proporciones de la actividad bacteriostática y bactericida, se realizó prueba de Fisher y T student (IC 95% p = 0,05). El halo de inhibición a una concentración del 100% mostró comportamiento similar a clorhexidina (p<0,05). Concentraciones al 100% y 80% fueron bactericidas, al 60%, 40% y 20% presentaron comportamiento bacteriostático. No se encontraron diferencias significativas en las proporciones de inhibición entre las dos variedades de mandarina (p>0,05). El uso de aceites esenciales de mandarina podría ser una alternativa complementaria al tratamiento de la enfermedad periodontal.Palabras clave: aceite esencial, agente antimicrobiano, cítrico, cavidad oral, odontopatógenos ARTÍCULO DE INVESTIGACIÓNRev.

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“…PLA secondary to F. nucleatum has rarely been reported previously, and mostly in immunodeficient hosts with the exception of a few (Tweedy and White 1987; Scoular et al 1992; Etienne et al 2001; Ala et al 2001; Wells et al 2005; Schattner and Gotler 2014; Dahya et al 2015; Ahmed et al 2015). We report the case of a 69 year-old immunocompetent female who was found to have a pyogenic liver abscess secondary to Fusobacterium nucleatum.…”

Section: Introductionmentioning

confidence: 96%

Fusobacterium nucleatum: a rare cause of pyogenic liver abscess

2015

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While pyogenic liver abscesses are uncommon, they are associated with significant mortality and morbidity. Most pyogenic liver abscesses are polymicrobial and are caused by enteric bacteria and anaerobes. Rarely, mono-microbial infections may occur, typically in immunocompromised individuals. We report the unusual case of a 69 year-old immunocompetent female who developed a pyogenic liver abscess due to Fusobacterium nucleatum infection, likely from a dental source. Poor oropharyngeal hygiene seems to have a major role in infection from this organism and therefore F. nucleatum should be considered as a differential for causes of pyogenic liver abscess in such patients. Drainage of the abscess and antibiotic therapy are the mainstays of therapy.

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Fusobacterium nucleatum Endocarditis Presenting as Liver and Brain Abscesses in an Immunocompetent Patient

Cited by 20 publications

References 6 publications

Concurrent fusobacterial pyogenic liver abscess and empyema

Concurrent fusobacterial pyogenic liver abscess and empyema

Efecto antimicrobiano del aceite esencial de Citrus reticulata sobre Fusobacterium nucleatum asociada a enfermedad periodontal

Fusobacterium nucleatum: a rare cause of pyogenic liver abscess

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