Fusobacterium nucleatum and oral cancer: a critical review

McIlvanna, Emily; Linden, Gerard; Craig, Stephanie G.; Lundy, Fionnuala; James, Jacqueline

doi:10.1186/s12885-021-08903-4

Cited by 74 publications

(59 citation statements)

References 112 publications

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“…Other studies have reported changes in microbial oral flora in patients with oral carcinomas (Martin and van Saene, 1992;Nagy et al, 1998;Anjali et al, 2020) and during radiation treatment (Llory et al, 1972;Brown et al, 1975;Keene et al, 1981;Keene and Fleming, 1987;Epstein et al, 1991;Abu Shara et al, 1993;Leung et al, 2001;Vissink et al, 2003b;Dahlen et al, 2009;Anjali et al, 2020;Zagury-Orly et al, 2021). These changes have also included an increase in Fusobacterium and Veillonella (Nagy et al, 1998;McIlvanna et al, 2021;Minarovits et al, 2021), as was found in this study.…”

Section: Discussionsupporting

confidence: 67%

Microbial Analysis of Obturators During Maxillofacial Prosthodontic Treatment Over an 8-Year Period

Lyons

Cannon

Beumer

et al. 2022

The Cleft Palate Craniofacial Journal

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The aim of the study was to investigate the microbial colonization (by Candida species, anaerobic and facultative anaerobic bacteria) of maxillary obturators used for the restoration of maxillary defects, including during radiotherapy. Retrospective cohort study. Fifteen patients requiring a maxillary obturator prosthesis had swabs of their obturators and adjacent tissues taken at different stages of their treatment over a period of 8 years. Identification of microbial species from the swabs was carried out using randomly amplified polymorphic DNA polymerase chain reaction (RAPD PCR) analysis, checkerboard DNA–DNA hybridization, CHROMagar Candida chromogenic agar, and DNA sequencing. Candida species were detected in all patients and all patients developed mucositis and candidiasis during radiotherapy which was associated with an increase in colonization of surfaces with Candida spp ., particularly C albicans. Microbial colonization increased during radiotherapy and as an obturator aged, and decreased following a reline, delivery of a new prosthesis, or antifungal treatment during radiotherapy. Microbial colonization of maxillary obturators was related to the stage of treatment, age of the obturator material, radiotherapy and antifungal medications, and antifungal treatment may be recommended if C albicans colonization of palatal tissues is greater than 105 colony-forming units per cm2 following the first week of radiotherapy.

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Section: Discussionsupporting

confidence: 67%

Microbial Analysis of Obturators During Maxillofacial Prosthodontic Treatment Over an 8-Year Period

Lyons

Cannon

Beumer

et al. 2022

The Cleft Palate Craniofacial Journal

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“…Because OLP is potentially cancerous, there is a risk that these bacteria may promote the conversion of OLP into OSCC, even if it is not clear whether these bacteria are the cause or result of OLP. Bacteria of Fusobacterium and Porphyromonas are mainly studied so far, both of which can promote the occurrence and development of OSCC through various mechanisms ( Li et al, 2020 ; Mcilvanna et al, 2021 ; Vyhnalova et al, 2021 ). The dominant bacteria of OSCC were different in different regions and stages ( Zhang et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Microbiome landscape of lesions and adjacent normal mucosal areas in oral lichen planus patient

et al. 2022

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The pathogenesis of oral lichen planus (OLP) remains unclear, and microbial dysbiosis has been proposed to play a role in the pathogenesis of OLP. Oral mucosal swabs from 77 OLP patients and 76 healthy subjects were collected. The bacterial community among the OLP lesion, the adjacent normal mucosal, and the oral mucosal surface in healthy people were analyzed by 16S sequencing. The factor of gender and age that may affect the flora distribution of OLP patients were explored. Results indicate no significant difference in microbiota between OLP and the adjacent group. Compared with the healthy group, Neisseria, Haemophilus, Fusobacterium, Porphyromonas, Rothia, Actinomyces, and Capnocytophaga significantly increased in the OLP group. Actinomyces increased in male OLP patients, and the other six bacteria increased in female OLP patients. In female OLP patients, Lautropia and Dialister were positively correlated with age. While in male OLP patients, Moraxella, Porphyromonas, and Fusobacterium were positively correlated with age. Functional enrichment analysis suggested that abnormal energy metabolism related to ATP synthases, abnormal transport and metabolism of glycans, amino acids, and vitamins, and disorders of the local immune microenvironment might exist in OLP lesion.

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“…This experimental periodontitis model was initiated by a 5-day placement of a ligature around the second maxillary molar tooth, followed by oral inoculation of Fusobacterium nucleatum to promote prolonged inflammation and dysbiosis. F. nucleatum can act as an anchoring perio-pathogen to initiate and support periodontitis biofilm formation ( Foster and Kolenbrander, 2004 ; Park et al, 2016 ; Thurnheer et al, 2019 ; Yamada et al, 2005 ; Yip et al, 2021 ) and induce chronic inflammation and immune evasion locally and systemically ( Hajishengallis and Chavakis, 2021 ; McIlvanna et al, 2021 ). Thus, by adapting the traditional ligature-induced PD model, we can examine initiating events in PD and later events because of prolonged inflammation and dysbiosis.…”

Section: Resultsmentioning

confidence: 99%