Fusobacterium nucleatum and brain abscess: Case report and literature review

Chaovarin, Chokchai; Polpong, Pongwat; Sungkhachat, Orawan

doi:10.1016/j.inat.2020.101062

Cited by 6 publications

(6 citation statements)

References 14 publications

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Section: Discussionmentioning

confidence: 99%

“…Bacteremia with Fusobacterium spp. accounts for less than 1% of all bacteremia and less than 10% for all anaerobic bacteremia cases in adults [ 7 ]. The majority of the infections caused by F. nucleatum occur in older patients with multiple chronic medical conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of the infections caused by F. nucleatum occur in older patients with multiple chronic medical conditions. While disseminated Fusobacterium infections spreading to the brain, liver, and other organs have been reported, they are not a common occurrence [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…A previous review of patients with F. nucleatum brain abscesses reported surgery in nine of 11 cases. Survival was 100% with more than half of the patients eventually achieving total recovery while five of the 11 had some residual neurological deficits [ 7 ]. One fatal case has been described in a young intravenous drug user with F. nucleatum abscess involvement of the cerebellum [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

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Fatal Case of Liver and Brain Abscesses Due to Fusobacterium nucleatum

Toumeh¹,

Mudireddy²,

Smith³

et al. 2021

Cureus

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Fusobacterium nucleatum is an anaerobic gram-negative organism regarded as an oral commensal. We present a case of a 63-year-old male presenting with weakness, encephalopathy and right upper quadrant palpable mass found to have F. nucleatum liver abscess with innumerable intracranial abscesses. F. nucleatum is a rare cause of concomitant liver and brain abscesses associated with odontogenic infection with potentially fatal outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fatal Case of Liver and Brain Abscesses Due to Fusobacterium nucleatum

Toumeh¹,

Mudireddy²,

Smith³

et al. 2021

Cureus

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“… 6 In fact, only 8 out of 12 cases of fusobacterial brain abscesses were recovered from cultures. 4 In contrast to bacterial culture, bacterial sequencing is able to identify a bacterial infection even with very low colony-forming units. The universal gene utilized for bacterial sequencing is the 16S rRNA gene, which is highly conserved in all bacteria.…”

Section: Discussionmentioning

confidence: 99%

Ruptured intraventricular brain abscesses due to Fusobacterium nucleatum with obstructive hydrocephalus: illustrative case

Srour¹,

Demand²,

Zhang

et al. 2023

Journal of Neurosurgery: Case Lessons

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BACKGROUND Fusobacterium spp. are strictly anaerobic microorganisms and normal flora of the oropharyngeal, gastrointestinal, and female genital tracts. It is commonly associated with periodontal disease, pharyngitis, mastoiditis, and tonsillitis, with a tendency to abscess formation. OBSERVATIONS The authors report a case of brain abscesses complicated by ventriculitis and obstructive hydrocephalus caused by Fusobacterium nucleatum of suspected odontogenic source. While repeated bacterial cultures remained negative, the isolate was identified using bacterial sequencing. LESSONS Empirical antimicrobial coverage for F. nucleatum should be considered in patients presenting with brain abscess. Genetic bacterial sequencing utilizing 16S ribosomal RNA molecular diagnostic testing may assist in microorganism identification to guide antimicrobial therapy.

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