Fusobacteriosis presenting as community acquired pneumonia

Bhattacharya, Sanjay; Livsey, S A; Wiselka, Martin; Bukhari, Sayed S.

doi:10.1016/j.jinf.2003.11.007

Cited by 10 publications

(8 citation statements)

References 8 publications

(3 reference statements)

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“…One hundred two studies were published from 1950 to 2007. Eighty‐four fulfilled our inclusion criteria, totaling 114 patients for review 3–86. Selection and information bias, lack of uniform reporting, and inclusion of low methodological quality studies prevented a formal meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

Lemierre's syndrome: A systematic review

et al. 2009

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Section: Resultsmentioning

confidence: 99%

Lemierre's syndrome: A systematic review

et al. 2009

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“…These are relevant items of information for the dental practitioner, as they may benefit the patients in several ways during dental procedures, such as for example, by reducing the odds of bacterial spread to other areas of the body, such as the eyes through aerosol, 11,32 or even into the lungs though inhalation. 33 The previous studies that have evaluated the effects of different antiseptics in reducing aerosol contamination, have recommended CHX as the gold standard. 3,4,13,34,35,36 CHX as a pre-procedural rinse has been compared with other antiseptics, such as essential oils, 13 povidone iodine and ozone, 36 tea tree oil, 35 a solution containing different types of herb extracts 4 and CPC.…”

Section: Discussionmentioning

confidence: 99%

“…3 This represents an additional beneficial effect of the pre-rinsing, since certain species from the orange complex, such as the Fusobacterium species, may be associated with the etiology of ophthalmic and respiratory infections. 32,33 One limitation of the present study is that it presents results for a single dental procedure, prophylaxis with an ultrasonic scaler that has been shown to have a great potential for aerosol generation in the dental office. 1,2,3,4,5,39 However, other dental procedures can also generate a large amount of aerosol with infectious components launched into the dental environment, such as the air turbine handpiece, 6,7 air-water from a three-way syringe 8 and sodium bicarbonate jet.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial

et al. 2017

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The aim of this randomized, single blinded clinical trial was to evaluate the effect of a pre-procedural mouthwash containing cetylpyridinium chloride (CPC), zinc lactate (Zn) and sodium fluoride (F) in the reduction of viable bacteria in oral aerosol after a dental prophylaxis with ultrasonic scaler. Sixty systemically healthy volunteers receiving dental prophylaxis were randomly assigned to one of the following experimental groups (15 per group): (i) rinsing with 0.075% CPC, 0.28% Zn and 0.05% F (CPC+Zn+F), (ii) water or (iii) 0.12% chlorhexidine digluconate (CHX), and (iv) no rinsing. Viable bacteria were collected from different locations in the dental office on enriched TSA plates and anaerobically incubated for 72 hours. The colonies were counted and species were then identified by Checkerboard DNA-DNA Hybridization. The total number of colony-forming units (CFUs) detected in the aerosols from volunteers who rinsed with CPC+Zn+F or CHX was statistically significantly (p<0.05) lower than of those subjects who did not rinse or who rinsed with water. When all locations were considered together, the aerosols from the CPC+Zn+F and CHX groups showed, respectively, 70% and 77% fewer CFUs than those from the No Rinsing group and 61% and 70% than those from the Water group. The mean proportions of bacterial species from the orange complex were statistically significantly (p<0.05) lower in aerosols from the CPC+Zn+F and CHX groups compared with the others two groups. In conclusion, the mouthwash containing CPC+Zn+F, is effective in reducing viable bacteria in oral aerosol after a dental prophylaxis with ultrasonic scaler.

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“…Bhattacharya et al (36) used activated protein C in a patient with typical Lemierre's syndrome associated with F. necrophorum who presented with hypotension, respiratory failure, and renal impairment. However, there are no data available on its efficacy specifically for F. necrophorum.…”

Section: Adjunctive Therapymentioning

confidence: 99%

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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SUMMARYSummary:Human infection withFusobacterium necrophorumusually involvesF. necrophorumsubsp.funduliformerather thanF. necrophorumsubsp.necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation. Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests thatF. necrophorumcan be limited to the throat and cause persistent or recurrent tonsillitis.F. necrophorumis unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection. In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat.

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Fusobacteriosis presenting as community acquired pneumonia

Cited by 10 publications

References 8 publications

Lemierre's syndrome: A systematic review

Lemierre's syndrome: A systematic review

Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

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