Fusobacterial head and neck infections in children

Brook, Itzhak

doi:10.1016/j.ijporl.2015.04.045

Cited by 34 publications

(36 citation statements)

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“…Indeed, few polymicrobial infections were observed although F necrophorum is known to multiply in synergism with other aerobic bacteria which increases its virulence. 1,2,10 The proportion of septic thrombosis due to F necrophorum in the present study was about 3 times higher than that observed In paediatric infectious thrombosis, anticoagulation use is still controversial. In the present series, whatever the microorganism responsible, more than 90% of children received anticoagulation.…”

Section: Comparisons With Other Studiescontrasting

confidence: 66%

“…Over the past decades, anaerobic bacteria emerged in head and neck infections, such as mastoiditis and ethmoiditis . F necrophorum now represents one of the most frequent anaerobic pathogen in otogenic infection.…”

Section: Discussionmentioning

confidence: 99%

“…In accordance with another study, the use of antibiotics in the present cohort was frequent before hospitalisation (59.6% herein vs 72%) and likely modified the culture results. Indeed, few polymicrobial infections were observed although F necrophorum is known to multiply in synergism with other aerobic bacteria which increases its virulence …”

Section: Discussionmentioning

confidence: 99%

“…Over the past decades, anaerobic bacteria emerged in head and neck infections, such as mastoiditis and ethmoiditis. 1,7 F necrophorum now represents one of the most frequent anaerobic pathogen in otogenic infection. This increase is not fully clarified but it is probably TA B L E 1 Comparison of biological, radiological and therapeutic data between the "OLST Fusobacterium group" and the "OLST other bacteria group"…”

Section: Fusobacterium Necrophorum: An Emerging Pathogenmentioning

confidence: 99%

“…Fusobacterium necrophorum , a Gram‐negative anaerobic bacillus, is known to be part of the oral cavity microbiome. In some cases, it can lead to invasive head and neck infections such as sinusitis, peritonsillar abscesses or mastoiditis . The increase in the incidence of Fusobacterium mastoiditis, particularly in healthy children, has been documented by several authors over the last decade .…”

Section: Introductionmentioning

confidence: 99%

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Fusobacterium necrophorum, a major provider of sinus thrombosis in acute mastoiditis: A retrospective multicentre paediatric study

Coudert

Fanchette

Regnier

et al. 2019

Clinical Otolaryngology

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Objective To evaluate in children the clinical severity and evolution of otogenic lateral sinus thrombosis (OLST) due to Fusobacterium necrophorum compared with other bacterial otogenic thrombosis and propose a specific management flowchart for Fusobacterium OLST. Design A retrospective multicentre cohort study. Settings Four French ENT paediatric departments. Participants A total of 260 under 18 years old admitted for acute mastoiditis were included. Initial imaging was reviewed to focus on complicated mastoiditis and 52 OLST were identified. Children were then divided into two groups according to bacteriological results: 28 in the “OLST Fusobacterium group” and 24 in the “OLST other bacteria group”. Results There was a significant association between F necrophorum and OLST (P < .001). When compared to the OLST other bacteria group, children in the OLST Fusobacterium group were significantly younger (61 months vs 23 months, P < .01) and had a more severe clinical presentation: higher CRP (113 mg/L vs 175.7 mg/L, P = .02) and larger subperiosteal abscess (14 mm vs 21 mm, P < .01). Medical management was also more intensive in the OLST Fusobacterium group than in the OLST other bacteria group: increased number of conservative surgeries (66.7% vs 92.9%, P = .03) and longer hospital stay (13.7 days vs 19.8 days, P = .02). At the end of follow‐up, the clinical course was good in both groups without any neurological sequelae. Conclusions Thrombotic complications are very frequent in case of Fusobacterium mastoiditis and clinicians should be aware of the initial severity of the clinical presentation. Under appropriate management, the clinical course of Fusobacterium OLST is as good as that of other bacterial otogenic thrombosis.

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Section: Comparisons With Other Studiescontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Fusobacterium Necrophorum: An Emerging Pathogenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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