Fusion Rates After Thoracoscopic Release and Bone Graft Substitutes in Idiopathic Scoliosis

Weinzapfel, Brett; Son-Hing, Jochen P.; Armstrong, Douglas G.; Blakemore, Laurel C.; Poe-Kochert, Connie; Thompson, George H.

doi:10.1097/brs.0b013e31816f69b3

Cited by 20 publications

(10 citation statements)

References 39 publications

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“…Price et al retrospectively analyzed the efficacy of DBM in combination with bone marrow for a posterior spinal fusion in 77 scoliosis cases, and found that the fusion rates were comparable to those of iliac bone autograft combined with DBM composites [47]. Weinzapfl et al [48] compared the use of allograft to DBM as a bone graft substitute in patients undergoing video assisted anterior thoracoscopic release and fusion for adolescent idiopathic scoliosis. At more than 1-year follow-up, fusion was observed on lateral radiographs in 82 % of the disc spaces in the allograft group and in 92 % in the DBM group, although this difference was not significant.…”

Section: Demineralized Bone Matrixmentioning

confidence: 99%

A systematic review of comparative studies on bone graft alternatives for common spine fusion procedures

et al. 2013

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Section: Demineralized Bone Matrixmentioning

confidence: 99%

A systematic review of comparative studies on bone graft alternatives for common spine fusion procedures

et al. 2013

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“…Four DBM products have been used in spinal surgery: Accell Connexus (Citagenix, Laval, Canada); Allomatrix; Grafton DBM; and Osteofil (Medtronic, Minneapolis, Minnesota). These DBM products were used as bone graft extenders in most studies; only in two studies 45 , 46 was Grafton DBM used as a bone graft substitute.…”

Section: Resultsmentioning

confidence: 99%

“…Grafton DBM was the only product also used for thoracic fusions. In a retrospective cohort, Weinzapfel et al 46 used Grafton DBM in patients who underwent anterior thoracic discectomies and compared their results with using morsellised cancellous allografts. On the final radiographs, 82% of the allograft group and 92% of the Grafton DBM group were rated as fused.…”

Section: Resultsmentioning

confidence: 99%

The available evidence on demineralised bone matrix in trauma and orthopaedic surgery

Stok

Hartholt

Schoenmakers

et al. 2017

Bone & Joint Research

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ObjectivesThe aim of this systematic literature review was to assess the clinical level of evidence of commercially available demineralised bone matrix (DBM) products for their use in trauma and orthopaedic related surgery.MethodsA total of 17 DBM products were used as search terms in two available databases: Embase and PubMed according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses statement. All articles that reported the clinical use of a DBM-product in trauma and orthopaedic related surgery were included.ResultsThe literature search resulted in 823 manuscripts of which 64 manuscripts met the final inclusion criteria. The included manuscripts consisted of four randomised controlled trials (level I), eight cohort studies (level III) and 49 case-series (level IV). No clinical studies were found for ten DBM products, and most DBM products were only used in combination with other grafting materials. DBM products were most extensively investigated in spinal surgery, showing limited level I evidence that supports the use Grafton DBM (Osteotech, Eatontown, New Jersey) as a bone graft extender in posterolateral lumbar fusion surgery. DBM products are not thoroughly investigated in trauma surgery, showing mainly level IV evidence that supports the use of Allomatrix (Wright Medical, London, United Kingdom), DBX (DePuy Synthes, Zuchwil, Switzerland), Grafton DBM, or OrthoBlast (Citagenix Laval, Canada) as bone graft extenders.ConclusionsThe clinical level of evidence that supports the use of DBM in trauma and orthopaedic surgery is limited and consists mainly of poor quality and retrospective case-series. More prospective, randomised controlled trials are needed to understand the clinical effect and impact of DBM in trauma and orthopaedic surgery.Cite this article: J. van der Stok, K. A. Hartholt, D. A. L. Schoenmakers, J. J. C. Arts. The available evidence on demineralised bone matrix in trauma and orthopaedic surgery: A systemati c review. Bone Joint Res 2017;6:423–432. DOI: 10.1302/2046-3758.67.BJR-2017-0027.R1.

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“…The greatest number of references were related to its usage in spinal fusion for deformity. 21,44,[53][54][55] Hedequist recently reported that freeze-dried allograft was equivalent to autograft for treatment of congenital scoliosis, an important finding as autograft for most of these children is not adequate. 56 There are also favorable report of its usage for treatment of benign and malignant bone tumors, 53,57 for foot osteotomies, 58,59 and iliac osteotomies.…”

Section: Pediatric Orthopaedic Applicationsmentioning

confidence: 99%

The Use of Bone Grafts and Bone Graft Substitutes in Pediatric Orthopaedics

Gross

2012

Journal of Pediatric Orthopaedics

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Bone graft substitutes have become progressively more widely used, and are currently heavily marketed. To make intelligent decisions, a complete knowledge of autograaft and allograft bone healing is essential, including the definition of "sterile". Differences in donor selection and tissue processing may confound the user not familiar with the implications of these different approaches. Specific products include demineralized bone matrix (DBM), specific growth factors (recombinant BMP's), ceramic grafts, and platelet-rich plasma (PRP). There are a number of useful applications of bone graft substitues for pediatric orthopaedists, but the data base is evolving. This paper describes the current status of these products.

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Fusion Rates After Thoracoscopic Release and Bone Graft Substitutes in Idiopathic Scoliosis

Abstract: Demineralized bone matrix (Grafton DBM Flex) seem to be an effective bone graft substitute in thoracoscopic surgery for idiopathic scoliosis.

Cited by 20 publications

References 39 publications

A systematic review of comparative studies on bone graft alternatives for common spine fusion procedures

A systematic review of comparative studies on bone graft alternatives for common spine fusion procedures

The available evidence on demineralised bone matrix in trauma and orthopaedic surgery

The Use of Bone Grafts and Bone Graft Substitutes in Pediatric Orthopaedics

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