Fusion Peptide-Engineered Polyetheretherketone Implants with Photo-Assisted Anti-Pathogen and Enhanced Angiogenesis for in vivo Osseointegrative Fixation

Material–Structure–Function Integrated Additive Manufacturing of Degradable Metallic Bone Implants for Load‐Bearing Applications

“…It indicates that the introduction of Cu element can effectively restrain the bacteria adhesion and perturb the metabolism of bacteria. [ 29 ] Furthermore, the topography and membrane integrity of E. coli and S. aureus treated with varying Zn alloy extracts were observed using SEM. Complete and smooth membrane structures can be found in Zn and Zn–Mg groups, while irregular shapes with rough and shriveled surfaces are detected in Zn–Mg–Cu group (Figure 4D).…”

“…[ 34 ] Meanwhile, implants’ capacity to construct host‐harmonized tissue microenvironments lies at the heart of bone regeneration. [ 29 ] This study proposes an MSFI‐AM strategy to develop degradable Zn–Mg–Cu scaffolds with integrated bio‐adaptable performance, TPMS structure, and bio‐multifunctions. Our research manifests that MSFI‐oriented Zn–Mg–Cu scaffolds possess moderate degradation rates and appropriate mechanical degeneration behavior at the early stage.…”

A One‐Stone‐Two‐Birds Strategy for Osteochondral Regeneration Based on a 3D Printable Biomimetic Scaffold with Kartogenin Biochemical Stimuli Gradient

“…In this work, we used KGN as the inducer for the simultaneous chondrogenic and osteogenic differentiation of BMSCs, as the common strategy of incorporating two or more bioactive signal molecules in different layers may induce potential antagonistic effects in therapy and encounter more hurdles in clinical translation. [ 19 ] The concentration of the drug inclusion complex Ac‐ β ‐CD[KGN] was set to 0.6 m m for CLH and 0.03 m m for OLH. [ 11,20 ] Based on the findings of Bian et al.…”

“…[3] In this work, we used KGN as the inducer for the simultaneous chondrogenic and osteogenic differentiation of BMSCs, as the common strategy of incorporating two or more bioactive signal molecules in different layers may induce potential antagonistic effects in therapy and encounter more hurdles in clinical translation. [19] The concentration of the drug inclusion complex Ac-𝛽-CD[KGN] was set to 0.6 mm for CLH and 0.03 mm for OLH. [11,20] Based on the findings of Bian et al [12] that KGN combined with an intracellular calcium increase led to the differentiation of BMSCs to osteoblasts, we investigated the effect of 𝛽-TCP (Ca 2+ supplier) incorporation on the physiochemical properties and bone regeneration of the OLH.…”

Engineered Bio‐Heterojunction with Infection‐Primed H2S Liberation for Boosted Angiogenesis and Infectious Cutaneous Regeneration

“…[8][9] Pathogen can be rapidly devastated by reactive oxygen species (ROS) or hyperthermia, [10][11][12][13] techniques, which are defined as photodynamic therapy (PDT) and photothermal therapy (PTT), respectively. [14][15][16][17] Nevertheless, the ROS storm in PDT is a double-edged sword and has been reported to inevitably cause endothelial cell dysfunction and inhibit angiogenesis. [18][19] To ameliorate the side effects of PDT, a potent phototherapeutic bacteriostat with enhanced angiogenic activity is required to remedy ROS shock during the repair of refractory infected wounds.…”