Fusicoccanes: diterpenes with surprising biological functions

Boer, Albertus H. de; Leeuwen, Ingrid J. de Vries-van

doi:10.1016/j.tplants.2012.02.007

Cited by 96 publications

(88 citation statements)

References 86 publications

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“…Fusicoccanes are potent phytotoxins known to be synthesized by a few fungal species [186]. Phomopsis amygdali causes wilting disease in trees and produces the diterpenoid fusicoccin A that binds and permanently activates plasma membrane H + -ATPase [186], which causes severe physiological effects in plants.…”

Section: Fusicoccanes and Other Diterpenoids Made By Monofunctional Ementioning

confidence: 99%

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Biosynthesis of Terpenoid Natural Products in Fungi

Schmidt‐Dannert

2014

Advances in Biochemical Engineering/Biotechnology

108

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Tens of thousands of terpenoid natural products have been isolated from plants and microbial sources. Higher fungi (Ascomycota and Basidiomycota) are known to produce an array of well-known terpenoid natural products, including mycotoxins, antibiotics, antitumor compounds, and phytohormones. Except for a few well-studied fungal biosynthetic pathways, the majority of genes and biosynthetic pathways responsible for the biosynthesis of a small number of these secondary metabolites have only been discovered and characterized in the past 5-10 years. This chapter provides a comprehensive overview of the current knowledge on fungal terpenoid biosynthesis from biochemical, genetic, and genomic viewpoints. Enzymes involved in synthesizing, transferring, and cyclizing the prenyl chains that form the hydrocarbon scaffolds of fungal terpenoid natural products are systematically discussed. Genomic information and functional evidence suggest differences between the terpenome of the two major fungal phyla--the Ascomycota and Basidiomycota--which will be illustrated for each group of terpenoid natural products.

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Section: Fusicoccanes and Other Diterpenoids Made By Monofunctional Ementioning

confidence: 99%

“…Phomopsis amygdali causes wilting disease in trees and produces the diterpenoid fusicoccin A that binds and permanently activates plasma membrane H + -ATPase [186], which causes severe physiological effects in plants. A related compound, cotylenin A, made by the fungus Cladosporium sp.…”

Section: Fusicoccanes and Other Diterpenoids Made By Monofunctional Ementioning

confidence: 99%

Biosynthesis of Terpenoid Natural Products in Fungi

Schmidt‐Dannert

2014

Advances in Biochemical Engineering/Biotechnology

108

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“…The two natural products fusicoccin A and cotylenin A were first described as agents acting on plants [47,48], but were later found to show activities toward human cells [49][50][51]. For example, fusicoccin A shows antitumor activity [52], promotes platelet aggregation [53] and stabilizes the inhibitory binding of 14-3-3 to ERa [54].…”

Section: Forskolinmentioning

confidence: 99%

Stabilization of protein–protein interactions by small molecules

Giordanetto¹,

Schäfer

Ottmann

2014

Drug Discovery Today

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“…Although a large number of fusicoccane diterpenes with various bioactivities have been characterised from plants and fungi (Muromtsev et al 1994;de Boer & de Vries-van Leeuwen 2012), trichocitrin (1) represents the first Trichoderma-derived and furan-bearing fusicoccane diterpene. As shown in Figure 2, a plausible biogenetic pathway is proposed for 1.…”

Section: Resultsmentioning

confidence: 99%