Fused Pyrrolo[2,3-c]carbazol-6-ones:  Novel Immunostimulants That Enhance Human Interferon-γ Activity

Synthesis of Novel 1-Substituted and 1,9-Disubstituted-1,2,3,4-tetrahydro-9H-Carbazole Derivatives as Potential Anticancer Agents

“…Treatment of 3c with thionyl chloride in pyridine caused cyclization to furnish [1,2,6]thiadiazin-5-oxide derivative 6 [9] via elimination of two moles of HCl. The elemental analysis and spectral data are in good agreement with the proposed structure.…”

“…Interferon-γ (IFN-γ) is a potent activator of the immune system and has been used in the treatment of infections in human. A fused pyrrolo [2,3-c]carbazol-6-one ( Figure 1) reportedly potentiates the INF-γ induction of MHC-class π molecules [2].…”

Synthesis of benzo[b]thieno‐ and benzo[b]furano‐[2,3‐a]pyrrolo[3,4‐c]carbazole‐5‐, ‐7‐ and ‐5,7‐dione

“…The proposed mechanism was a tandem Michael-acid catalyzed condensation sequence [8]. Similar conditions using indoles 6 and 7 also underwent this reaction sequence to produce the 6-oxo carbazoles [10]. While investigating a number of reaction conditions it was determined that Michael adducts 8 and 9 could be isolated in good yield (70-90%) by treating 6 or 7, respectively with a 1.1 equivalents of maleimide and catalytic trifluoroacetic acid at toluene reflux.…”

Synthesis, Antimicrobial Screening and In Silico Appraisal of Iminocarbazole Derivatives

“…The antibacterial activity observed for murrayanine, extracted from the stem bark of Murraya Koenigii (Rutaceae), unravels the new era for the development of carbazole‐based scaffolds for pharmaceutical applications . Carbazole motifs demonstrate versatile pharmacological activities, such as 5‐HT 7 R blocking activity (VII), antibacterial, anti‐oxidant, antidiabetic, antifungal, antihistaminic, neuroprotective, antitumor, antiviral, antitubercular, antipsychotic and anticonvulsant activities –. Glycozoline (I) like carbazole alkaloids were reported for their antibiotic activity .…”