Fused heterocycles. Part 4. Synthesis and stereochemistry of hexahydrobenzo[6,7]cyclohepta[1,2-c]pyrazoles

Abstract

Hexahydrobenzo[6,7]cyclohepta[l,2-c] pyrazoles have been synthesized by treating 2benzylidene-Ibenzosuberone with hydrazine derivatives. The cis and trans isomers have been distinguished and conformational equilibria studied by NMR techniques.

Synthesis of 1-substituted 5-aryl-3-(3-coumarinyl)-2-pyrazolines by the reaction of 3-aryl-1-(3-coumarinyl)propen-1-ones with hydrazines

“…2-Pyrazolines became the most frequently studied pyrazoline type compounds and various methods have been worked out for their synthesis [19][20][21]. Since the milestone work of Fischer and Knövenagel published in the late nineteenth century [22], the reaction of α,β-unsaturated aldehydes and ketones with hydrazines became a generally used simple and convenient procedure for the preparation of 2-pyrazolines [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. As a consequence, numerous substituted 2-pyrazolines have been synthesized for various purposes.…”

“…As a consequence, numerous substituted 2-pyrazolines have been synthesized for various purposes. To continue our previous studies in this field [31][32][33]37,38,[40][41][42], herein we describe the synthesis of 1-substituted 5-aryl-3-(3coumarinyl)-2-pyrazolines by the reaction of (3coumarinyl)-chalcones and hydrazines.Results and Discussion.…”

Fused heterocycles 11.1 Synthesis of tricyclic fused pyrazolines by the reaction of 3-arylidenechromanones and 3-arylidene-1-thiochromanones with hydrazine

“…6,7 Synthesis of tricyclic fused pyrazolines by the reaction of exocyclic α,β-unsaturated ketones and hydrazines has also been studied by several research groups. 1,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] As a continuation of our activity on the investigation of the reaction of …”

Synthesis of chlorinated 3,5-diaryl-2-pyrazolines by the reaction of chlorochalcones with hydrazines

“…As a result, numerous substituted 2-pyrazolines have been synthesized, which has made possible structureactivity relationship investigations of these substances. As a continuation of our previous studies in this field, [23][24][25]29,30,[34][35][36] we report here the synthesis of new 1-substituted 3,5-diaryl-2-pyrazolines which are chlorinated in their aromatic rings.…”