Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines

Cailleaux, Sylvain; Sanchez‐Ballester, Noelia M.; Gueche, Yanis A.; Bataille, Bernard; Soulairol, Ian

doi:10.1016/j.jconrel.2020.10.056

Cited by 103 publications

(57 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The contact causes the filament to soften into a semi-solid state that forms the sequential layers by extrusion. The heating head or a bed moves in three dimensions, which allows the layers to deposit with great precision [111]. This extrusion method is widely employed for thermo-responsive polymers allowing larger constructs than other alternatives [112].…”

Section: D Printingmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

View full text Add to dashboard Cite

Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

show abstract

Section: D Printingmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Different 3D printing techniques have been investigated to produce SOFs such as binder and material jetting [ 17 , 18 , 19 ], fused deposition modeling (FDM) [ 20 , 21 , 22 ], semi-solid extrusion (SSE) [ 23 , 24 ], stereolithography (SLA) [ 25 , 26 ] and selective laser sintering (SLS) [ 27 ]. Although since 2014 the majority of the articles has focused on FDM technology, describing it as the most promising [ 28 ]; SLS has gained considerable attention in the last four years (from 2017 to 2020) accumulating a total of 14 research articles [ 27 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ] and two reviews [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Selective Laser Sintering (SLS), a New Chapter in the Production of Solid Oral Forms (SOFs) by 3D Printing

et al. 2021

Self Cite

View full text Add to dashboard Cite

3D printing is a new emerging technology in the pharmaceutical manufacturing landscape. Its potential advantages for personalized medicine have been widely explored and commented on in the literature over recent years. More recently, the selective laser sintering (SLS) technique has been investigated for oral drug-delivery applications. Thus, this article reviews the work that has been conducted on SLS 3D printing for the preparation of solid oral forms (SOFs) from 2017 to 2020 and discusses the opportunities and challenges for this state-of-the-art technology in precision medicine. Overall, the 14 research articles reviewed report the use of SLS printers equipped with a blue diode laser (445–450 nm). The review highlights that the printability of pharmaceutical materials, although an important aspect for understanding the sintering process has only been properly explored in one article. The modulation of the porosity of printed materials appears to be the most interesting outcome of this technology for pharmaceutical applications. Generally, SLS shows great potential to improve compliance within fragile populations. The inclusion of “Quality by Design” tools in studies could facilitate the deployment of SLS in clinical practice, particularly where Good Manufacturing Practices (GMPs) for 3D-printing processes do not currently exist. Nevertheless, drug stability and powder recycling remain particularly challenging in SLS. These hurdles could be overcome by collaboration between pharmaceutical industries and compounding pharmacies.

show abstract

“…The potential and cost-effectiveness of 3D printing in the manufacturing of personalized and innovative drug products, especially when small batches are involved, were largely confirmed in the last five years [30][31][32][33][34]. Great attention is currently being paid to versatility-oriented design strategies and scale-down fabrication opportunities, which could better suit the rising needs of precision medicine [35][36][37][38]. This involves tailoring the medical treatment to the peculiar characteristics of small groups of patients or even to those of each individual, and could include type, dose, administration mode, composition and release performance of the DDS under development.…”

Section: Introductionmentioning

confidence: 99%

The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM)

et al. 2021

View full text Add to dashboard Cite

The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting configuration, entailing a gastroresistant film to prevent early interaction of the inner coat with gastric fluids and enabling the attainment of a lag phase matching the small intestinal transit time. Over the years, various multiple-step manufacturing processes have been tested for the fabrication of the Chronotopic™ system in both its configurations. This work focused on the evaluation of 3D printing by fused deposition modeling in view of its potential towards product personalization, on demand one-step manufacturing and efficient scale down of batches. The feasibility of each part of the Chronotopic™ system was independently investigated starting from in-house made filaments, characterizing the resulting specimens for physico-technological and performance characteristics. The printing parameters identified as suitable during the set-up phase were then used to fabricate prototypes either in a single step for the pulsatile configuration or following two different fabrication approaches for the colon-targeting one.

show abstract

Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines

Cited by 103 publications

References 112 publications

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Selective Laser Sintering (SLS), a New Chapter in the Production of Solid Oral Forms (SOFs) by 3D Printing

The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM)

Contact Info

Product

Resources

About