Fusarium solani infection during treatment for acute leukemia

Cho, Cheng T.; Vats, Tribhawan S.; Lowman, James T.; Brandsberg, John W.; Tosh, Fred E.

doi:10.1016/s0022-3476(73)80543-8

Cited by 117 publications

(38 citation statements)

References 7 publications

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“…Disseminated invasive fusariosis was first reported in 1973 (42). Since then, several other cases and a few small series of systemic fusarial hyalohyphomycosis in immunosuppressed patients have been reported (1,6,8,26,63,106,132,137,140,144,145,147,161,169,187,189,219,230,232,234,243,263,265), with a significant increase being noted recently.…”

Section: Esophageal Cancermentioning

confidence: 97%

Taxonomy, biology, and clinical aspects of Fusarium species

1994

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There are several taxonomic systems available for identifying Fusarium species. The philosophy used in each taxonomic system is discussed as well as problems encountered in working with Fusarium species in culture. Fusarium species are toxigenic, and the mycotoxins produced by these organisms are often associated with animal and human diseases. The implications for the association of the carcinogens, fumonisins, produced by Fusarium moniliforme and other Fusarium species with human diseases are discussed. Foreign-body-associated fusarial infection such as keratitis in contact lens wearers, onychomycosis, skin infections, and disseminated multiorgan infections are discussed. Disseminated fusarial hyalohyphomycosis has emerged as a significant, usually fatal infection in the immunocompromised host. Successful outcome is determined by the degree of immunosuppression, the extent of the infection, and the presence of a removable focus such as an indwelling central venous catheter. These infections may be clinically suspected on the basis of a constellation of clinical and laboratory findings, which should lead to prompt therapy, probably with one of the newer antifungal agents. Perhaps the use of such agents or the use of colony-stimulating factors may improve the outcome of this devastating infection. However, until new approaches for treatment develop, effective preventive measures are urgently needed.

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Section: Esophageal Cancermentioning

confidence: 97%

Taxonomy, biology, and clinical aspects of Fusarium species

1994

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“…Erythematous macules, purpura and necrosis are the most common skin lesions seen in patients with dissemi nated fusariosis [7,8], The site of entry of the fungus might be through intravascular catheters (9], sinus [10] or the gas trointestinal tract [11], Biopsies and cultures from skin lesions help to reveal fungal infection. The white powder found on the necrotic lesions in this patient revealed fungal infection as well, though this seems to be an unusual and probably late man ifestation of the disease.…”

Section: Discussionmentioning

confidence: 99%

<i>Fusarium</i> Infection with Unusual Skin Lesions in a Patient with Acute Lymphocytic Leukemia

1995

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A 27-year-old woman with acute lymphocytic leukemia developed red painful skin lesions, asymmetrically distributed over the face and extremities. They gradually increased in size and number, and in the center of each lesion blisters appeared followed by central necrosis with surrounding erythema. In several lesions the central necrosis was covered with a white powder shown to be fungal mycelium. Cultures from skin lesions and blood showed a Fusarium species. The skin lesions are helpful in recognizing this deep fungal infection in an immunocompromised host.

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“…11 published cases [2,[4][5][6][7][8][9][10][11], the majority being caused by F. solani. Eight of the referred cases were comInfected mice developed systemic illness characterized mainly by neurological abnormalities, such as conplications of acute leukaemia [2,[4][5][6][7][8], one was associated with corticoid therapy [9] and in the two remaining vulsive movements and torticollis.…”

Section: Clinical Coursesmentioning

confidence: 99%

“…Eight of the referred cases were comInfected mice developed systemic illness characterized mainly by neurological abnormalities, such as conplications of acute leukaemia [2,[4][5][6][7][8], one was associated with corticoid therapy [9] and in the two remaining vulsive movements and torticollis. However, important variations were recorded among the members of each cases no other pathological findings were detected in the patients, making them exceptional [10,11].…”

Section: Clinical Coursesmentioning

confidence: 99%

Endogenous endophthalmitis byFusarium solani: an animal experimental model

Mayayo

Guarro²,

Pujol³

1998

Med Mycol

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An experimental model of endophthalmitis by Fusarium solani in immunocompetent mice that could be useful for evaluating the efficacy of different treatments and the pathogenicity of the fungus in ocular structures was established. Five clinical isolates of F. solani were injected into the lateral tail vein of groups of 20 mice, in order to produce systemic infection with ocular infection. Inocula of 5×10 6 conidia per mouse were used. The eyes of the animals that died were enucleated for histopathological study to determine the degree of ocular infection. We found fungal infections in 34% of the mice studied. Panophthalmitis was detected in 16 animals, four with bilateral infections. Fungal endophthalmitis can become a severe complication of systemic mycoses by F. solani.

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Fusarium solani infection during treatment for acute leukemia

Cited by 117 publications

References 7 publications

Taxonomy, biology, and clinical aspects of Fusarium species

Taxonomy, biology, and clinical aspects of Fusarium species

<i>Fusarium</i> Infection with Unusual Skin Lesions in a Patient with Acute Lymphocytic Leukemia

Endogenous endophthalmitis byFusarium solani: an animal experimental model

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