Fusarium Head Blight Control and Prevention of Mycotoxin Contamination in Wheat with Botanicals and Tannic Acid

Forrer, Hans‐Rudolf; Musa, Tomke; Schwab, Fabienne; Jenny, Eveline; Bucheli, Thomas D.; Wettstein, Felix E.; Vogelgsang, Susanne

doi:10.3390/toxins6030830

Cited by 29 publications

(24 citation statements)

References 36 publications

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“…General antifungal and antibacterial activity of tannic acid, for example, has been known for a long time [30,31,32] and activity against Fusarium graminearum was recently experimentally shown [34]. Our analysis presents several possible protein targets for tannic acid, including carbonic anhydrases and a bromodomain adjacent to the zinc finger domain 2B, both having homolog in the Fusarium graminearum sequence.…”

Section: Resultsmentioning

confidence: 99%

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Metabolomics and Cheminformatics Analysis of Antifungal Function of Plant Metabolites

Čuperlović-Culf¹,

Rajagopalan²,

Tulpan³

et al. 2016

Metabolites

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Fusarium head blight (FHB), primarily caused by Fusarium graminearum, is a devastating disease of wheat. Partial resistance to FHB of several wheat cultivars includes specific metabolic responses to inoculation. Previously published studies have determined major metabolic changes induced by pathogens in resistant and susceptible plants. Functionality of the majority of these metabolites in resistance remains unknown. In this work we have made a compilation of all metabolites determined as selectively accumulated following FHB inoculation in resistant plants. Characteristics, as well as possible functions and targets of these metabolites, are investigated using cheminformatics approaches with focus on the likelihood of these metabolites acting as drug-like molecules against fungal pathogens. Results of computational analyses of binding properties of several representative metabolites to homology models of fungal proteins are presented. Theoretical analysis highlights the possibility for strong inhibitory activity of several metabolites against some major proteins in Fusarium graminearum, such as carbonic anhydrases and cytochrome P450s. Activity of several of these compounds has been experimentally confirmed in fungal growth inhibition assays. Analysis of anti-fungal properties of plant metabolites can lead to the development of more resistant wheat varieties while showing novel application of cheminformatics approaches in the analysis of plant/pathogen interactions.

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Section: Resultsmentioning

confidence: 99%

“…Metabolic changes resulting from FHB infection in resistant or less susceptible plants have been explored in wheat [5,24,25,32,33,34] and barley [23,35]. Anti-fusarium metabolites have also been explored in chickpeas, and their effect was tested for protection of wheat from FHB [27].…”

Section: Resultsmentioning

confidence: 99%

Metabolomics and Cheminformatics Analysis of Antifungal Function of Plant Metabolites

Čuperlović-Culf¹,

Rajagopalan²,

Tulpan³

et al. 2016

Metabolites

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show abstract

“…Application of resistant cultivars, plant extracts and essential oils, such as thymol oil and Galla chinensis extract, are the most effective, economic, and environmentally safe ways to control plant diseases (Forrer et al 2014;Khaledi et al 2015;Lenc et al 2015;Gill et al 2016). To date, two main types of resistance to FHB are widely accepted: type I -resistance to initial infection, type II -resistance to fungal spread within the spike.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of resistance and the role of some defense responses in wheat cultivars to Fusarium head blight

Khaledi¹,

Taheri²,

Falahati-Rastegar³

2018

Journal of Plant Protection Research

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Fusarium graminearum and F. culmorum are the causal agents of Fusarium head blight (FHB) in cereal crops worldwide. Application of resistant cultivars is the most effective and economic method for management of FHB and reducing mycotoxin production in wheat. Understanding the physiological and biochemical mechanisms involved in basal resistance of wheat to FHB disease is limited. In this research, after screening resistance levels of eighteen wheat cultivars planted in Iran, Gaskozhen and Falat were identified as partially resistant and susceptible wheat cultivars against Fusarium spp., respectively. Also, we investigated the role of hydroxyl radical (OH − ), nitric oxide (NO), callose deposition, lipid peroxidation and protein content in basal resistance of wheat to the hemi-biotrophic and necrotrophic Fusarium species causing FHB. Nitric oxide as a signaling molecule may be involved in physiological and defensive processes in plants. Our results showed that NO generation increased in seedlings and spikes of wheat cultivars after inoculation with Fusarium species. We observed earlier and stronger callose deposition at early time points after infection by Fusarium spp. isolates than in non-infected plants, which was positively related to the resistance levels in wheat cultivars. Higher levels of OH − and malondialdehyde (MDA) accumulation (as a marker of lipid peroxidation) were observed in the Falat than in the Gaskozhen cultivar, under non-infected and infected conditions. So, estimation of lipid peroxidation could be useful to evaluate cultivars' susceptibility. These findings can provide novel insights for better recognition of physiological and biochemical markers of FHB resistance, which could be used for rapid screening of resistance levels in wheat cultivars against this destructive fungal disease.

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“…Forrer et al, 2014) permitted within organic production systems are used in combination with agromanagement tools such as water and soil conservation.…”

Section: Pre-harvest Objectivesmentioning

confidence: 99%

Safe food and feed through an integrated toolbox for mycotoxin management: the MyToolBox approach

Krska

Nijs

McNerney

et al. 2016

WMJ

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There is a pressing need to mobilise the wealth of knowledge from the international mycotoxin research conducted over the past 25-30 years, and to perform cutting-edge research where knowledge gaps still exist. This knowledge needs to be integrated into affordable and practical tools for farmers and food processors along the chain in order to reduce the risk of mycotoxin contamination of crops, feed and food. This is the mission of MyToolBox -a four-year project which has received funding from the European Commission. It mobilises a multi-actor partnership (academia, farmers, technology small and medium sized enterprises, food industry and policy stakeholders) to develop novel interventions aimed at achieving a significant reduction in crop losses due to mycotoxin contamination. Besides a field-to-fork approach, MyToolBox also considers safe use options of contaminated batches, such as the efficient production of biofuels. Compared to previous efforts of mycotoxin reduction strategies, the distinguishing feature of MyToolBox is to provide the recommended measures to the end users along the food and feed chain in a web-based MyToolBox platform (e-toolbox). The project focuses on small grain cereals, maize, peanuts and dried figs, applicable to agricultural conditions in the EU and China. Crop losses using existing practices are being compared with crop losses after novel pre-harvest interventions including investigation of genetic resistance to fungal infection, cultural control (e.g. minimum tillage or crop debris treatment), the use of novel biopesticides suitable for organic farming, competitive biocontrol treatment and development of novel modelling approaches to predict mycotoxin contamination. Research into post-harvest measures includes real-time monitoring during storage, innovative sorting of crops using vision-technology, novel milling technology and studying the effects of baking on mycotoxins at an industrial scale.

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Fusarium Head Blight Control and Prevention of Mycotoxin Contamination in Wheat with Botanicals and Tannic Acid

Cited by 29 publications

References 36 publications

Metabolomics and Cheminformatics Analysis of Antifungal Function of Plant Metabolites

Metabolomics and Cheminformatics Analysis of Antifungal Function of Plant Metabolites

Evaluation of resistance and the role of some defense responses in wheat cultivars to Fusarium head blight

Safe food and feed through an integrated toolbox for mycotoxin management: the MyToolBox approach

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