Fusaric acid accelerates the senescence of leaf in banana when infected by Fusarium

Dong, Xian; Xiong, Yinfeng; Ling, Ning; Guo, Shiwei

doi:10.1007/s11274-013-1564-1

Cited by 47 publications

(38 citation statements)

References 40 publications

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“…The production and phytotoxic properties of FA have been studied over the past 75 years (Bacon et al, 1996;Dong et al, 2014;G€ aumann, 1957, 1958Yabuta et al, 1937), and a number of mechanisms for FA toxicity have been suggested, most related to modifications in the plant cell membrane (D'Alton and Etherton, 1984). To test FA toxicity, roots of 3-week-old tomato plants were immersed in sterile water with or without FA.…”

Section: Fa Toxicity In Tomato Plants Is Reversed By the Exogenous Admentioning

confidence: 99%

“…FA is one of the first fungal toxins for which a functional role in virulence has been proposed (G€ aumann, 1957, 1958) and several studies have provided circumstantial evidence linking FA production to plant pathogenicity (Dong et al, 2014;Gapillout et al, 1996;Venter and Steyn, 1998). However, to date, no formal proof for such a role has been provided.…”

Section: Mechanism Of Fa Phytotoxicity and Role In Virulencementioning

confidence: 99%

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Fusaric acid contributes to virulence of Fusarium oxysporum on plant and mammalian hosts

López‐Díaz

Rahjoo

Sulyok

et al. 2017

Molecular Plant Pathology

106

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Fusaric acid (FA) is amongst the oldest identified secondary metabolites produced by Fusarium species, known for a long time to display strong phytotoxicity and moderate toxicity to animal cells; however, the cellular targets of FA and its function in fungal pathogenicity remain unknown. Here, we investigated the role of FA in Fusarium oxysporum, a soil-borne cross-kingdom pathogen that causes vascular wilt on more than 100 plant species and opportunistic infections in humans. Targeted deletion of fub1, encoding a predicted orthologue of the polyketide synthase involved in FA biosynthesis in F. verticillioides and F. fujikuroi, abolished the production of FA and its derivatives in F. oxysporum. We further showed that the expression of fub1 was positively controlled by the master regulator of secondary metabolism LaeA and the alkaline pH regulator PacC through the modulation of chromatin accessibility at the fub1 locus. FA exhibited strong phytotoxicity on tomato plants, which was rescued by the exogenous supply of copper, iron or zinc, suggesting a possible function of FA as a chelating agent of these metal ions. Importantly, the severity of vascular wilt symptoms on tomato plants and the mortality of immunosuppressed mice were significantly reduced in fub1Δ mutants and fully restored in the complemented strains. Collectively, these results provide new insights into the regulation and mode of action of FA, as well as on the function of this phytotoxin during the infection process of F. oxysporum.

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Section: Fa Toxicity In Tomato Plants Is Reversed By the Exogenous Admentioning

confidence: 99%

Section: Mechanism Of Fa Phytotoxicity and Role In Virulencementioning

confidence: 99%

Fusaric acid contributes to virulence of Fusarium oxysporum on plant and mammalian hosts

López‐Díaz

Rahjoo

Sulyok

et al. 2017

Molecular Plant Pathology

106

View full text Add to dashboard Cite

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“…Foc stimulates pathogen-induced necrosis in later stages of infection However, wilt causing Fusarium fungi shows a short biotrophic phase during establishment in the host plant and later enters the necrotrophic phase, thereby making it a hemibiotroph (Thaler et al 2004;Bhadauria et al 2009). Plant cell death also occurs due to potent phytotoxins such as fusaric acid (Laluk & Mengistea 2010) and beauvericin (BEA) (Li et al 2011b;Li et al 2013a;Dong et al 2014) secreted by Foc during infection. Fusaric acid is a known potent phytotoxin that induces senescence in the infected banana leaves (Dong et al 2014), whereas BEA inhibits cholesterol acyltransferase and induces typical programmed cell death.…”

Section: Fusarium Wilt Disease Cyclementioning

confidence: 99%

“…Plant cell death also occurs due to potent phytotoxins such as fusaric acid (Laluk & Mengistea 2010) and beauvericin (BEA) (Li et al 2011b;Li et al 2013a;Dong et al 2014) secreted by Foc during infection. Fusaric acid is a known potent phytotoxin that induces senescence in the infected banana leaves (Dong et al 2014), whereas BEA inhibits cholesterol acyltransferase and induces typical programmed cell death. BEA also induces pore formation in biological membranes (Wu et al 2008;Stenglein 2009;Stipanovic et al 2011).…”

Section: Fusarium Wilt Disease Cyclementioning

confidence: 99%

Fusarium wilt of banana: biology, epidemiology and management

Ghag

Shekhawat

Ganapathi

2015

International Journal of Pest Management

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Fusarium oxysporum is a soil borne hyphomycete that causes vascular wilts in several crop plants. A variety of remedial measures such as the use of fungicides, soil amendments and biological antagonists have proved insufficient in controlling F. oxysporum. Ever since it was first reported in banana crop, the only effective control strategy known is planting of resistant cultivars. However, presumably due to the high mutation rates and rapid co-evolution with its host, Fusarium wilt has surmounted host defense barriers and has already begun infecting even the resistant Cavendish varieties that dominate export markets worldwide. Transgenic banana plants showing enhanced resistance to Fusarium wilt have been developed in recent past, but they remain largely confined to the laboratory. The importance of banana as source of food and income in developing countries world over and the need to develop Fusarium wilt tolerant cultivars by novel biotechnological approaches is detailed herein. In this communication, we review the biology and management of Fusarium wilt in banana with the aim of providing the baseline of information to encourage much needed research on integrated management of this destructive banana crop disease problem.

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“…It was indicated by the development of wilting or yellowing leaves (Dong et al, 2012). Fusaric acid was a phytotoxin produced by Foc which disrupted the permeability of plant membrane, inhibited the oxygen taking and had important role as causal agent of yellowing leaves and enhanced the aging process on infected plants (Dong et al, 2014).…”

Section: Disease Progressmentioning

confidence: 99%

Race and Virulence Determination of Fusarium oxysporum f. sp. cubense Isolates from Sidomulyo Village of Bantul, Yogyakarta

Jayatri

Sumardiyono

Wibowo

2018

JPTI

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Banana is one of the important fruit crop in Village of Sidomulyo, Bantul, Yogyakarta. One of important diseases which become the constraint in development of banana is Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc). This fungus has high race diversity and virulence, so that it required early detection for prevention and control of disease. This experiment was aimed to figure out race and virulence of Foc isolates from Village of Sidomulyo, Bantul, Yogyakarta. The 13 tested isolates were isolates of PR11, PKJ20, RU20, PR30, AH40, PKJ40, A41, RB42, PR43, RU51, A60, RP60, and A80. Race was molecularly detected using two types of primers, i.e. General Foc primer FocEf3 and specific primer for race 4 (Foc-1/Foc-2). Virulence test was performed on banana seedlings of Ambon Kuning cultivar using Completely Randomized Design (CRD) with 14 treatments and 4 repetitons. The observed parameters were external and internal symptoms, calculation of disease severity index and disease intensity. Data were analyzed using variance and further test of Duncan Multiple Range Test (DMRT) at 5 % level. The results showed that all isolates were Foc and 9 of 13 isolates were grouped into race 4, i.e. A80, RP60, PR11, A41, AH40, PKJ40, PR30, RB42, and PR43. The highest and lowest virulences were consecutively expressed by PR30, RB42, RU51, RP60, PR43, PKJ40, PR11, A41, AH40, RU20, PKJ20, A60, and A80, with severity index on leaves and rhizomes ranging 1.61-2.91 and 2.25-7, respectively. IntisariPisang merupakan tanaman buah unggulan di Desa Sidomulyo Kecamatan Bambanglipuro, Kabupaten Bantul. Salah satu penyakit penting yang menjadi kendala dalam pengembangan pisang adalah layu fusarium yang disebabkan oleh jamur Fusarium oxysporum f. sp. cubense (Foc). Jamur ini memiliki keragaman ras dan virulensi yang tinggi, sehingga deteksi dini diperlukan untuk pencegahan dan pengendalian penyakit. Penelitian ini bertujuan untuk mengetahui ras dan virulensi isolat Foc asal Desa Sidomulyo, Kecamatan Bambanglipuro, Kabupaten Bantul. Isolat yang diuji sebanyak 13 isolat, yakni isolat PR11, PKJ20, RU20, PR30, AH40, PKJ40, A41, RB42, PR43, RU51, A60, RP60, dan A80. Pengujian ras secara molekuler dengan menggunakan dua jenis primer yakni primer Foc in general FocEf3 dan primer spesifik ras 4 Foc-1/Foc-2. Uji virulensi pada bibit kultivar ambon kuning dengan menggunakan Racangan Acak Lengkap (RAL) yang terdiri dari 14 perlakuan dan 4 ulangan. Parameter yang diamati berupa pengamatan gejala luar dan gejala dalam, penghitungan indeks keparahan penyakit dan intensitas penyakit. Analisis data menggunakan sidik ragam dan uji lanjut Duncan Multiple Range Test (DMRT) pada taraf 5 %. Hasil pengujian menunjukkan bahwa semua isolat merupakan isolat Foc dan dari 13 isolat yang digunakan terdapat 9 isolat yang merupakan ras 4 yakni isolat A80, RP60, PR11, A41, AH40, PKJ40, PR30, RB42, dan PR43. Isolat yang memiliki virulensi tertinggi sampai terendah berturut-turut adalah PR30, RB42, RU51, RP60, PR43, PKJ40, PR11, A41, AH40, RU20, PKJ20, A60, dan A80, dengan indeks keparahan pada daun berkisar 1,61−2,91 dan indeks keparahan pada bonggol 2,25−7.

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Fusaric acid accelerates the senescence of leaf in banana when infected by Fusarium

Cited by 47 publications

References 40 publications

Fusaric acid contributes to virulence of Fusarium oxysporum on plant and mammalian hosts

Fusaric acid contributes to virulence of Fusarium oxysporum on plant and mammalian hosts

Fusarium wilt of banana: biology, epidemiology and management

Race and Virulence Determination of Fusarium oxysporum f. sp. cubense Isolates from Sidomulyo Village of Bantul, Yogyakarta

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