Further validation of magnifying chromocolonoscopy for differentiating colorectal neoplastic polyps in a health screening center

Emura, Fabián; Saito, Yutaka; Taniguchi, Makoto; Fujii, Takeshi; Tagawa, Kazumi; Yamakado, Minoru

doi:10.1111/j.1440-1746.2007.04975.x

Cited by 29 publications

(19 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ferrara et al (10) concluded that bleeding was significantly related to malignancy, as observed in one of our cases. Perforation has been reported as occurring in 0% to 4% of cases (3,15,18,22) .…”

Section: Discussionmentioning

confidence: 62%

“…Several studies have shown the efficacy of high-magnification chromocolonoscopy, through pit pattern analysis, in differentiating neoplastic from non-neoplastic lesions, with an accuracy of 80.1% to 99.1% (10,12,16,23,26,40,43,50,51) . Recent studies have reported an agreement of 96.8% for lesions up to 2.0 cm and 94.9% for lesions up to 1.0 cm in diameter (9,41) .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Endoscopic mucosal resection in colorectal lesion: a safe and effective procedure even in lesions larger than 2 cm and in carcinomas

Santos¹,

Malaman²,

Pereira-Lima

2011

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -Endoscopic mucosal resection is a minimally invasive technique used in the treatment of colorectal neoplasms, including early carcinomas of different size and morphology. Objectives -To evaluate procedure safety, efficacy, outcomes, and recurrence rate in endoscopic mucosal resection of colorectal lesions. Methods -A total of 172 lesions in 156 patients were analyzed between May 2003 and May 2009. All lesions showed pit pattern suggestive of neoplasia (Kudo types III-V) at high-magnification chromocolonoscopy with indigo carmine. The lesions were evaluated for macroscopic classification, size, location, and histopathology. Lesions 20 mm or smaller were resected en bloc and lesions larger than 20 mm were removed using the piecemeal technique.Complications and recurrence were analyzed. Patients were followed up for 18 months. Results -There were 83 (48.2%) superficial lesions, 57 (33.1%) depressed lesions, 44 (25.6%) laterally spreading tumors, and 45 (26.2%) protruding lesions. Mean lesion size was 11.5 mm ± 9.6 mm (2 mm-60 mm). Patients' mean age was 61.6 ± 12.5 years (34-93 years). Regarding lesion site, 24 (14.0%) lesions were located in the rectum, 68 (39.5%) in the left colon, and 80 (46.5%) in the right colon (transverse, ascending, and cecum). There were 167 (97.1%) neoplasms: 142 (82.5%) adenomatous lesions, 24 (14.0%) intramucosal carcinomas, and 1 (0.6%) invasive carcinoma. En bloc resection was performed in 158 (91.9%) cases and piecemeal resection in 14 (8.1%). Bleeding occurred in 5 (2.9%) cases. Recurrence was observed in 4.1% (5/122) of cases and was associated with lesions larger than 20 mm (P<0.01), piecemeal resection (P<0.01), advanced neoplasm (P = 0.01), and carcinoma compared to adenoma (P = 0.04). Conclusions -Endoscopic mucosal resection of colorectal lesions is a safe and effective procedure, with low complication and local recurrence rates. Recurrence is associated with lesions larger than 20 mm and carcinomas.

show abstract

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Endoscopic mucosal resection in colorectal lesion: a safe and effective procedure even in lesions larger than 2 cm and in carcinomas

Santos¹,

Malaman²,

Pereira-Lima

2011

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

“…Indigo-carmine dye was sprayed on previously resected areas and high-magnification views were obtained in all cases. Recurrent neoplastic disease was identified as type IIIs, IIIL, IV or V pit pattern according to the criteria established by Kudo and Fujii [6,9,10,[30][31][32][38][39][40][41].…”

Section: Follow-up Endoscopic Carementioning

confidence: 99%

Clinical outcome of endoscopic submucosal dissection versus endoscopic mucosal resection of large colorectal tumors as determined by curative resection

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…In adults, several studies have validated these techniques in differentiating neoplastic from non-neoplastic lesions [26][27][28][29] , diagnosis of neoplastic lesions in flat and depressed lesions in the colorectum, and in cancer surveillance in patients with long-standing ulcerative colitis [30,31] . Confocal endomicroscopy is a newly developed tool that enables surface and subsurface imaging of living cells in the mucosa during ongoing endoscopy.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders

Venkatesh¹,

Cohen²,

Evans³

et al. 2009

WJG

View full text Add to dashboard Cite

AIM:To evaluate the feasibility and utility of confocal laser endomicroscopy (CLE) in the description of normal gastrointestinal (GI) mucosa and in the diagnosis of GI disorders in children, in comparison to histology. METHODS:Forty-four patients (19 female) median age 10.9 years (range 0.7-16.6 years) with suspected or known GI pathology underwent esophago-gastroduodenoscopy (OGD) (n = 36) and/or ileocolonoscopy (IC) (n = 31) with CLE using sodium fluorescein and acriflavine as contrast agents. Histological sections were compared with same site confocal images by two experienced pediatric and GI histopathologists and endoscopists, respectively. RESULTS:Duodenum and ileum were intubated in all but one patient undergoing OGD and IC. The median procedure time was 16.4 min (range 7-25 min) for OGD and 27.9 min (range 15-45 min) for IC. A total of 4798 confocal images were compared with 153 biopsies from the upper GI tract from 36 procedures, and 4661 confocal images were compared with 188 biopsies from the ileocolon from 31 procedures. Confocal images were comparable to conventional histology both in normal and in pathological conditions such as esophagitis, Helicobacter pylori gastritis, celiac disease, inflammatory bowel disease, colonic heterotopia, and graft versus host disease.CONCLUSION: CLE offers the prospect of targeting biopsies to abnormal mucosa, thereby increasing diagnostic yield, reducing the number of biopsies, decreasing the burden on the histopathological services, and reducing costs.

show abstract

Further validation of magnifying chromocolonoscopy for differentiating colorectal neoplastic polyps in a health screening center

Abstract: Magnifying chromocolonoscopy is superior to conventional chromocolonoscopy for the diagnosis of colorectal neoplastic lesions in the setting of a health testing center.

Cited by 29 publications

References 39 publications

Endoscopic mucosal resection in colorectal lesion: a safe and effective procedure even in lesions larger than 2 cm and in carcinomas

Endoscopic mucosal resection in colorectal lesion: a safe and effective procedure even in lesions larger than 2 cm and in carcinomas

Clinical outcome of endoscopic submucosal dissection versus endoscopic mucosal resection of large colorectal tumors as determined by curative resection

Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders

Contact Info

Product

Resources

About