Further terpenoids from the Chloranthaceae plant Chloranthus multistachys and their anti-neuroinflammatory activities

Wang, Xuejiao; Yu, Sheng-Zhou; Xin, Jun-Li; Pan, Li-Long; Xiong, Juan; Hu, Jin‐Feng

doi:10.1016/j.fitote.2021.105068

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…41 The LS trimer trishizukaol A (336) could effectively inhibit the levels of IL-6, ROS, and TNF-a, and promote the level of IL-10 by targeting TRAF6. (195) showed great antineuroinammatory activity by inhibiting the production of NO in BV2 cells, [213][214][215] especially, shizukaol B (169) inhibited the secretion of IL-1b and the expression of JNK, NOS, and COX-2 and blocked the DNA binding activity of AP-AP-1 to relieve neuroinammation. 213 Lindenenyl acetate (2) effectively prevented glutamate-induced oxidative damage and showed strong neuroprotective effects against glutamate-induced neurotoxicity by inducing HO-1 expression in mouse hippocampal HT22 cells.…”

Section: Anti-inammatory Activitymentioning

confidence: 99%

Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers

Luo,

Zhang,

Tang

et al. 2024

Nat. Prod. Rep.

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Section: Anti-inammatory Activitymentioning

confidence: 99%

Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers

Luo,

Zhang,

Tang

et al. 2024

Nat. Prod. Rep.

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“…) C.Pei & San, C. multistachys, etc.) (Zhang et al 2016;Zhuo et al 2017;Chang-heng et al 2020;Liu et al 2022;Wang et al 2022). In a recent review of the genus Chloranthus, Liu et al (2022) reported that 418 secondary metabolites were isolated from several Chloranthus species, including terpenoids, coumarins, lignans, phenylpropanoids, flavonoids, amides, organic acids, and so on (Liu et al 2022).…”

Section: Key To Speciesmentioning

confidence: 99%

“…In a recent review of the genus Chloranthus, Liu et al (2022) reported that 418 secondary metabolites were isolated from several Chloranthus species, including terpenoids, coumarins, lignans, phenylpropanoids, flavonoids, amides, organic acids, and so on (Liu et al 2022). Previous pharmacological reports of Chloranthus species have shown various modern pharmacological properties, including anti-tumor, anticancer, anti-inflammatory, antibacterial, antiviral, antimalarial, neuroprotective, and hypoglycemic (Zhang et al 2016;Zhuo et al 2017;Chang-heng et al 2020;Liu et al 2022;Wang et al 2022). These pharmacological effects are due to the biologically active groups of active ingredients that are identified in the Chloranthus species (Zhang et al 2016;Liu et al 2022).…”

Section: Key To Speciesmentioning

confidence: 99%

Micromorphology, physicochemical parameters, and phytochemical screening of Chloranthus flavus D.T. Liu & G. Chen (syn. C. nervosus Collett & Hemsl.) from Vietnam

CHEN,

LAM,

KHAI

et al. 2024

Biodiversitas

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Abstract. Chen TV, Lam DNX, Khai HD, Duc DPN, Nga NT, Hien NTT, Quynh TTT. 2024. Micromorphology, physicochemical parameters, and phytochemical screening of Chloranthus flavus D.T. Liu & G. Chen (syn. C. nervosus Collett & Hemsl.) from Vietnam. Biodiversitas 25: 846-858. Chloranthus flavus D.T. Liu & G. Chen (syn. C. nervosus Collett & Hemsl.) is a subshrub belonging to the family Chloranthaceae. Information on the anatomical structure and the powder features of C. flavus has not been noted. This study aimed to develop a monograph on the microscopic characteristics and physicochemical parameters of C. flavus, as well as a preliminary assessment of the phytochemical composition of this species. Anatomical characterizations of roots, stems, and leaves were performed using the iodine green-carmine staining method and then an optical microscope was used to observe the histology of these parts, similar to observing powder characteristics. Secondary metabolites were detected by chromogenic or precipitation reagents. Anatomically, the structural characteristics of the roots, stems, and leaves are similar to those of the Chloranthus species. Particularly, the root structure is characterized by six alternating xylem bundles, with six phloem bundles forming a ring. Polygonal to irregularly shaped cells of the upper epidermis and irregularly shaped ordinary cells, laterocytic and anomocytic stomata types, stomatal clusters, and the stomatal index (15.75±1.52%) of the lower epidermis were observed in leaves. Both powders found fragments of epidermal and parenchymatous cells, spiral xylem vessels, and scalariform xylem vessels. However, the root powder only observed solid-shaped sclereid cells, starch granules, starch clusters, and calcium oxalate crystals. The powders' moisture content, total ash, and acid-insoluble ash values all meet acceptable standards according to regulations on raw material purity. The whole C. flavus plant contains carotenoids, fatty acids, essential oils, flavonoids, tannins, coumarins, alkaloids, triterpenoids, amino acids, and carbohydrates. The current findings highlight the key characteristics for identifying C. flavus.

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