Further Studies on Urinary Aldosterone in Human Arterial Hypertension.

Abstract

t We found recently that these contaminants interfere little with the isonicotinic acid hydrazide reaction described reoen,tly by Weichselbaum and Margraf and which depends on the presence of a A4-3 ketone group (8).

Aldosterone Secretion and Primary and Malignant Hypertension *

“…The findings reported here perhaps confirm in part the work of Genest and associates (8) who reported increased urinary excretion of aldosterone in some patients with malignant hypertension. However, these workers also found increased aldosterone excretion in milder forms of hypertension, and this latter finding is at variance with our data.…”

“…In addition, other studies have suggested that abnormalities of intracellular sodium and potassium content may occur in patients with arterial hypertension (7). Genest, Koiw, Nowaczynski and Lebouef (8) ported that the urinary excretion of aldosterone was significantly increased in 55 per cent of their patients with hypertension of diverse etiologies. The increased levels of urinary aldosterone were not correlated with any abnormality of sodium or potassium metabolism, nor did the increased values appear to be specifically associated with any particular type of hypertensive disease.…”

The Aldosterone Blocking Effects of Spirolactones

“…The dose of Aldactone will depend on the response produced but it should be increased if necessary to 800 or 1200 mg per day. Similar results have been obtained by Genest (20,57). In contrast, patients with renal hypertension seldom experience a fall in blood pressure.…”

Influence of the Pituitary and the Renin-Angiotensin System on the Secretion of Aldosterone, Cortisol, and Corticosterone

“…This is based on morphological studies in the rat (1), on indirect assessments of adrenal secretion during metabolic studies in man (2), and on direct estimations of adrenal hormone secretion in the rat (3,4) and dog (5)(6)(7). The morphological studies of Deane and Masson (8), which indicate that renin may stimulate the adrenal cortex in the rat, the results of Genest and his colleagues (9), which suggest that arterial hypertension may be associated with an increased excretion of aldosterone in man, and the demonstration by Genest ( 10,11 ) and Laragh (12) and their colleagues that angiotensin II stimulates excretion (10,11) and secretion (12,13) of aldosterone suggest that the kidney may have some influence on the rate of secretion of adrenal hormones. Recently, Pronove, MacCardle, and Bartter (14) described a dwarfed, normotensive child who was suffering from the effects of excessive production of aldosterone.…”