Further Studies on the Role of the Uterus in the Regulation of Corpus Luteum Function in Sheep

Caldwell, Burton V.; Moor, R. M.

doi:10.1530/jrf.0.0260133

Cited by 18 publications

(10 citation statements)

References 7 publications

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“…(6) Infusion and cross-circulation experiments have demonstrated the presence of a luteolysin in utero-ovarian venous blood at the time of luteolysis [13][14][15]54]. …”

Section: Evidence That There Is a Luteolysin Of Uterine Originmentioning

confidence: 99%

“…This view was strengthened by the fact that luteolysis could be prevented in some cases by very large doses of a ganglion-blocking drug. However, the infusion or cross-circulation experiments referred to earlier [13][14][15]54] previously found that luteal maintenance resulted from ligation of the uterine vein and artery, but not from ligation of the uterine artery alone. Baird & Land ligated the uterine vein(s) proximal to the entry of the ovarian vein, with the intention of preventing PGF2a from gaining access to that segment of uterine vein where it is in very close apposition to the ovarian artery.…”

Section: Pgf2a Is the Uterine Luteolysinmentioning

confidence: 99%

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The Demonstration That Pgf2 Is the Uterine Luteolysin in the Ewe

Goding¹

1974

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123

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“…(6) Infusion and cross-circulation experiments have demonstrated the presence of a luteolysin in utero-ovarian venous blood at the time of luteolysis [13][14][15]54]. …”

Section: Evidence That There Is a Luteolysin Of Uterine Originmentioning

confidence: 99%

Section: Pgf2a Is the Uterine Luteolysinmentioning

confidence: 99%

The Demonstration That Pgf2 Is the Uterine Luteolysin in the Ewe

Goding¹

1974

Reproduction

123

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“…Recent experimental evidence has suggested that prostaglandin (PG) F-2ct, released naturally from the uterus towards the end of the oestrous cycle, may be the agent responsible for initiating luteal regression (McCracken, Glew & Scaramuzzi, 1970;Caldwell & Moor, 1971 ;Wilson, Cenedella, Butcher & Inskeep, 1972). Chamley et al (1972) infused PGF-2a into the ovarian artery of ewes with ovarian transplants and demonstrated that it induced luteal regression and oestrus as¬ sociated with the typical rises in oestradiol-17ß and LH.…”

Section: Introductionmentioning

confidence: 99%

Plasma progesterone and LH concentrations in ewes after injection of an analogue of prostaglandin F-2

Acritopoulou¹,

Haresign²,

Foster³

et al. 1977

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Plasma progesterone and LH concentrations were monitored throughout a natural oestrous cycle in 12 Clun Forest ewes and compared to those following treatment with a single i.m. injection of 100 microng ICI 80,996, an analogoue of prostaglandin F-2alpha, given during the luteal phase of the cycle. After injection of the analogue there was a high degree of synchrony in the return of oestrus (440 +/- 1-9 h; mean +/- S.E.M.) and the timing of the LH peak (48-5 +/- 2-0 h) from injection. There were no significant differences in the plasma progesterone concentrations or in the height and duration of the preovulatory LH peak between control and treatment cycles. The technique offers the possibility of controlled ovulation in the ewe.

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“…This preparation has been used successfully for demonstrating the luteolytic activity of PGF2a when infused through the ovarian artery (McCracken, Glew & Scaramuzzi, 1970;Barrett et al, 1971). Preliminary experiments suggest that uterine venous blood collected at the time of luteal regression may contain luteolytic activity (Caldwell & Moor, 1971;McCracken et al, 1971). After the operation, the donor ewes were tested for oestrus once a day and daily samples of uterine venous blood were collected as long as the catheter remained patent.…”

Section: Introductionmentioning

confidence: 99%