1979
DOI: 10.1111/j.1365-2184.1979.tb00148.x
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FURTHER STUDIES ON MOBILIZATION OF CFUs

Abstract: Mobilization of CFUs from haemopoietic tissues into circulation was studied after injection of different bacterial lipopolysaccharides (LPS), zymosan, phytohaemagglutinin (PHA), concanavalin A (Con A), trypsin and di‐isopropyl‐fluorophosphate‐inhibited trypsin. All bacterial LPS used gave an increase of CFUs in the peripheral blood at 1 h after i.v. injection. Some variation in activity could not be excluded. As with Salmonella typhosa LPS, zymosan gave an increase in circulating CFUs during the first few hr a… Show more

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Cited by 14 publications
(13 citation statements)
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“…[32][33][34] We therefore hypothesized that low levels of endotoxins passing through the intestinal mucosa into the blood may contribute to the levels of circulating HPCs. Here, we used a mouse model to study the effects of selective antibiotic decontamination on cytokine-induced stem cell mobilization.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…[32][33][34] We therefore hypothesized that low levels of endotoxins passing through the intestinal mucosa into the blood may contribute to the levels of circulating HPCs. Here, we used a mouse model to study the effects of selective antibiotic decontamination on cytokine-induced stem cell mobilization.…”
Section: Introductionmentioning
confidence: 99%
“…Endotoxins are also known as potent inducers of mobilization following systemic administration. 32,33 Under clinical and experimental conditions the lipopolysaccharide component of the aerobic Gram-negative bacteria wall damages the endothelial cell 48 finally leading to the synthesis and the release of proinflammatory mediators (TNF, IL-1, IL-6, and IL-8) from macrophages. 49 The endotoxin concentration in the gut is very likely to be decreased by the treatment with polymyxin B or metronidazol, resulting in a diminished production of cytokines by macrophages.…”
mentioning
confidence: 99%
“…This hypothesis is unlikely in view of the marked and selective enhancement of BFU-E proliferation and the dramatic increase of their pools in blood and spleen. It must be pointed out, however, that migration of both early hemopoietic precursors and stem cells is not restricted to leukemic diseases but has also been reported in stress erythropoiesis (11) and after injection of zymosan (17). On the other hand, in view of the fact that the BFU-E is closely related to the CFU-S (18), the possibility should be considered in future studies that the latter also represents a target cell for FLV.…”
Section: Discussionmentioning
confidence: 99%
“…1 and 3B). On the other hand, in FLV-A-infected mice, the plateau phase of BFU-E in the blood on days [10][11][12][13][14][15][16][17][18][19][20] was associated with a decrease in the number of BFU-E in the spleen, apparently due to differentiation of BFU-E to CFU-E (Figs. 1 and 2B).…”
Section: Clonal Analysis Of Erythroid Precursors In Marrowmentioning
confidence: 99%
“…At lower doses it induces a biphasic mobilization of haemopoietic progenitor cells and the production of auto-antibodies and circulating immune complexes (CICs) [Vos et al, 1972;Vos and Wilschut, 1979;Cun ningham, 1974;Fournié et al, 1974;Izui et al, 1977a;Rose et al, 1982;Bloembergen et al, 1987].…”
Section: Introductionmentioning
confidence: 99%