Further Studies on Anti-Thyroxine Effects of Various Compounds.

Abstract

-4NTI-THYROXINE EFFECTS OF I'ARIOUS COMPOUNDSdoses of cortisone acetate to immature rats maintained on a synthetic diet resulted in retarded growth, alopecia and death. These effects were largely counteracted by the administration of desiccated whole liver when fed at a level of 10% of the diet. The protective factor(s) in liver was distinct from any of the known B vitamins.

Recent Work on Thyroid Hormones

“…The observation by Barker, Dirks, Garlick and Klitgaard (1951) that BHDB also antagonized thyroxine in thyroidectomized rats was in agreement with this hypothesis.…”

The biological action of substances related to thyroxine. 8. The effects of butyl 4-hydroxy-3:5-diiodobenzoate on the deiodination of diiodotyrosine and thyroxine in rats

“…Indeed, the experiments of Gross & Leblond (1951 a, b) in which triiodothyronine was found in the plasma and excreta of both intact and thyroidectomized rats treated with radioactive thyroxine have been interpreted by Gross & Pitt-Rivers (1952b) as a probable indication of this process. If triiodothyronine is the active form of the hormone then extra-thyroidal sites must be at least as important in deiodination as the thyroid, since thyroidectomized animals respond to thyroxine and to anti-thyroxine compounds (Barker, Dirks, Garlick & Klitgaard, 1951). The observation of that BHDB inhibited the effect of thyroxine in intact mice, but enhanced that of triiodothyronine, is also consistent with the view that triiodothyronine arises as the result of deiodination of thyroxine.…”

The Sulfur Analog of Serotonin

“…The synthesis of this compound lias proved to be refractory. 3 We wish to report the synthesis of 3-(banhnoothyl)-')-hydraxybenzo|b]thiophene (I), and preliminary pharmacological evaluation. I 3-Methyl-5-hydroxybcnzo [6]thiophene,4 prepared by the cyclization procedure3 from ?n-hydroxyacetophenone, followed by decarboxylation of the resulting 3methyl-5-hydroxybenzo [b]thiophenc-2-carboxylie acid, was converted to its benzoate ester.…”