Further studies on anthelmintic resistance in sheep at an organised farm in arid region of Rajasthan

Swarnkar, C.P.; Khan, Farman Ali; Singh, D.; Bhagwan, P. S. K.

doi:10.1016/s0304-4017(98)00265-9

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…These findings are against previous studies that reported no resistance against ABZ in sheep [36,37] . Sargison [38] reported multiple anthelmintic resistances in sheep and goat.…”

Section: Discussioncontrasting

confidence: 56%

Pakistan’ın Kuzey Punjab Eyaletindeki Koyun ve Keçilerde Haemonchus contortus ve Teladorsagia circumcincta’nın Anthelmentiklere Karşı Direncinin Belirlenmesi

Muhammad¹,

Ahmed²,

Iqbal³

et al. 2015

Kafkas Univ Vet Fak Derg

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The present study was conducted to investigate the efficacy of albendazole, levamisole and ivermectin against gastrointestinal nematodes of sheep and goats. One hundred and sixty small ruminants comprised four breeds, sheep (Salt range and Pak Karakul) and goats (Jattal and Beetal) were selected for this experiment. These animals were artificially infected with nematodes (Haemonchus contortus and Teladorsagia circumcincta). FECs were done to confirm the presence of adult stages of H. contortus and T. circumcincta. The selected sheep and goat were divided into four groups. First group was treated with albendazole, second with levamisole, third with ivermectin and fourth kept as untreated to serve as control. Faecal samples were collected on day first prior to administration of treatment followed by day 14 post treatment. The efficacy of each anthelmintic was measured using the faecal egg count reduction test and egg hatch test. The percentage reduction in FECs (95% CI) for albendazole, levamisole and ivermectin for salt range sheep were 88%, 89% and 99%, for Pak karakul sheep, 91%, 90% and 97%, for Jattal goat 91%, 91% and 98%, and for Beetal goat 91%, 92% and 99%. All results showed the presence of multiple anthelmintic resistances in selected sheep and goats flocks. All flocks were found resistance against the albendazol and three were resistance against levamisole. The arithmetic faecal egg count reduction with albendazole, levamisole and ivermectin recorded for H. contortus and T. circumcincta indicated the resistance against albendazole and levamisole and susceptibility of these worms against ivermectin. The results revealed that a significant difference (P<0.05) of FECRT were found on pre-treatment and post-treatment with different anthelmintic drug as compared to control group in all the flocks. The results of egg hatch test indicated that LC 50 were ranged from 0.138 µg/mL to 0.141 µg/mL for four breeds, which were more than 0.1ug/ml of albendazole. Result indicates that resistance was found in the eggs with albendazole. The egg hatch assay also confirmed the result of faecal egg count reduction test. gününde dışkı örnekleri toplandı. Herbir anthelmentiğin etkinliği dışkı yumurta sayımı azalma testi ve yumurta açılımı testi ile belirlendi. Albendazol, levamizol ve ivermektin için dışkı yumurta sayımında % azalma Salt range koyununda sırasıyla %88, %89 ve %99, Pak karakul koyununda %91, %90 ve %97, Jattal keçisinde %91, %91 ve %98, ve Beetal keçisinde %91, %92 ve %99 olarak tespit edildi. Çalışmanın sonuçları seçilen koyun ve keçi sürülerinde anthelmentik direncin mevcut olduğunu göstermiştir. Tüm sürüler albendazola karşı dirençli bulunurken üçü levamizole karşı dirençliydi. H. contortus ve T. circumcincta için albendazol, levamizol ve ivermektin ile tespit edilen aritmetik dışkı yumurta sayımı azalma albendazol ve levamizole karşı direnci gösterirken ivermektine karşı duyarlılığı ortaya koymuştur. Tüm sürülerde kontrol grubu ile karşılaştırıldığında uygulama öncesi ve sonrası arasında dışkı yumur...

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“…These findings are against previous studies that reported no resistance against ABZ in sheep [36,37] . Sargison [38] reported multiple anthelmintic resistances in sheep and goat.…”

Section: Discussioncontrasting

confidence: 56%

Pakistan’ın Kuzey Punjab Eyaletindeki Koyun ve Keçilerde Haemonchus contortus ve Teladorsagia circumcincta’nın Anthelmentiklere Karşı Direncinin Belirlenmesi

Muhammad¹,

Ahmed²,

Iqbal³

et al. 2015

Kafkas Univ Vet Fak Derg

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“…drug residue in milk and meat and also economically viable (Humbert et al, 2001). As a result of their continued use, resistance to BZ drugs has emerged world-wide within trichostrongylid parasitic nematodes including India (Gill, 1993;Waller, 1997;Jackson and Coop, 2000;Swarnkar et al, 1999aSwarnkar et al, , 1999bSwarnkar et al, , 2001.…”

Section: Issn: 2319-7706 Volume 7 Number 02 (2018)mentioning

confidence: 99%

“…Physiological phenomena can also contribute to development of resistant population. In ruminant animals, the esophageal groove reflex can result in drug getting into an inappropriate compartment, where it is rendered ineffective or less effective resulting in enhanced rate of development (or) selection of resistant worms (Hennessy, 1994;Sanyal, 1994;Sanyal and Godke, 1996;Swarnkar et al, 1999a;Singh et al, 2002). Pharmacokinetics differences between individual animals and breeds of the same species can effect dose requirements and contribute to resistant population (Coles et al, 1989;Sangster et al, 1991).…”

Section: Manymentioning

confidence: 99%

Benzimidazole Resistance: An Overview

Bhinsara¹,

Sankar²,

Desai³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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Influence of sustained deworming pressure on the anthelmintic resistance status in strongyles of sheep under field conditions

Vijayasarathi

Sreekumar²,

Venkataramanan³

et al. 2016

Trop Anim Health Prod

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Anthelmintic resistance (AR) status in Madras Red sheep from selected field flocks of a government funded scheme, covered by regular, sustained anthelmintic treatment for more than 10 years was determined. Parameters such as fecal egg count reduction test (FECRT), larval paralysis assay (LPA), and allele-specific-PCR (AS-PCR) were used to test the efficacy of fenbendazole, tetramisole, and ivermectin at recommended doses, in two seasons. Sheep belonging to non-beneficiary farmers were used as controls. Mean FECRT values of beneficiary group during winter and summer seasons were 77.77 and 76.04, 93.65 and 92.12, and 95.37 and 98.06 %, respectively, for fenbendazole, tetramisole, and ivermectin. In the non-beneficiary groups, the corresponding values were 74.82 and 81.09 %, 96.05 and 97.40 %, and 97.26 and 98.23 %, respectively. The results revealed resistance to fenbendazole, suspect resistance to tetramisole and susceptibility to ivermectin in beneficiary flock. In non-beneficiary flock, while resistance was noticed against fenbendazole, both tetramisole and ivermectin were effective. FECR values were found to be significantly different between beneficiary and non-beneficiary groups against tetramisole. The results of LPA confirmed this finding, as 50 % of the Haemonchus contortus larvae were paralyzed at the concentration of 0.0156 μg/ml in the beneficiary group, while those of non-beneficiary groups required lower concentrations of 0.0078 μg/ml. AS-PCR revealed the predominance of heterozygous susceptible population of H. contortus in the beneficiary group. In this study, resistance to fenbendazole was confirmed in both the beneficiary and non-beneficiary groups and this could be attributed to frequent use of benzimidazoles as seen from the deworming records. Emergence of tetramisole resistance was detected in the beneficiary group, where the drug was used continuously for 4 years. Ivermectin was found to be effective in all the flocks. It is recommended that the practice of routine deworming of three to four times a year should be avoided, as it can lead to emergence of anthelmintic resistance.

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Further studies on anthelmintic resistance in sheep at an organised farm in arid region of Rajasthan

Cited by 9 publications

References 4 publications

Pakistan’ın Kuzey Punjab Eyaletindeki Koyun ve Keçilerde Haemonchus contortus ve Teladorsagia circumcincta’nın Anthelmentiklere Karşı Direncinin Belirlenmesi

Pakistan’ın Kuzey Punjab Eyaletindeki Koyun ve Keçilerde Haemonchus contortus ve Teladorsagia circumcincta’nın Anthelmentiklere Karşı Direncinin Belirlenmesi

Benzimidazole Resistance: An Overview

Influence of sustained deworming pressure on the anthelmintic resistance status in strongyles of sheep under field conditions

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