Further studies on analgesic activity of cyclic imides

Filho, Valdir Cechinel; Corrêa, Rogério; Vaz, Zulma R.; Calixto, João B.; Nunes, Ricardo José; Pinheiro, T. R.; Andricopulo, Adriano D.; Yunes, Rosendo A.

doi:10.1016/s0014-827x(97)00006-2

Cited by 68 publications

(51 citation statements)

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“…Since some cyclic imides have been described as antimicrobial agents (Haergreaves, 1970;Corrê a et al, 1996;Cechinel Filho et al, 2003), we have evaluated possible antibacterial effects against selected pathogens. The results indicated in Table I for S2, S3, L1 and F1 show their antibacterial activity, which inhibited bacterial growth at the concentration used.…”

Section: Discussionmentioning

confidence: 99%

“…7), but the most cytotoxic compound to this cell line was the maleimide S2.2, that drastically reduced the viability at a low concentration. This is a very important result because this cell line has a high resistance to the treatment with conventional antineoplasic agents (Senff-Ribeiro et al, 2003;Vicente et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…In the assessment of biological properties of new compounds, several models have been used (Cadena et al, 1998(Cadena et al, , 2002Senff-Ribeiro et al, 2003, 2004. We evaluated the effects of several related cyclic imide compounds: maleimides (S2, S2.1, S2.2, S3), glutarimides (S4, S5, S6), 4-aminoantipyrine derivatives (L1, F1, AL1, F1.14, F1.2) and sulfonated succinimides (RO1, FA, FE, FD, (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Biological Evaluation of Some Selected Cyclic Imides: Mitochondrial Effects and in vitro Cytotoxicity

Prado

Cechinel‐Filho²,

Buzzi

et al. 2004

Zeitschrift Für Naturforschung C

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Cyclic imides such as succinimides, maleimides, glutarimides, phthalimides and their derivatives contain an imide ring and a general structure -CO-N(R)-CO-that confers hydrophobicity and neutral characteristic. A diversity of biological activities and pharmaceutical uses have been attributed to them, such as antibacterial, antifungal, antinociceptive, anticonvulsant, antitumor. In spite of these activities, much of their action mechanisms at molecular and cellular levels remain to be elucidated. We now show the effects of several related cyclic imides: maleimides (S2, S2.1, S2.2, S3), glutarimides (S4, S5, S6), 4-aminoantipyrine derivatives (L1, F1, AL1, F1.14, F1.2) and sulfonated succinimides (RO1, FA, FE, FD, MC, DMC) on isolated rat liver mitochondria, B16-F10 melanoma cell line, peritoneal macrophages and different bacterial streams. The effects on mitochondrial respiratory parameters, cell viability and antibacterial activity were also evaluated. The results indicated that S3, S5 and S6 caused an increased oxygen consumption in the presence of ADP (state III) or its absence (state IV), while all other compounds decreased those parameters at different degrees of inhibition. All the compounds decreased the respiratory control coefficient (RCC). Loss of cell viability of peritoneal macrophages and the B16-F10 cell line was observed, L1 and S2.1 being more effective. S1, S2, S3, L1 and F1 compounds showed antibacterial activity at experimental concentrations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biological Evaluation of Some Selected Cyclic Imides: Mitochondrial Effects and in vitro Cytotoxicity

Prado

Cechinel‐Filho²,

Buzzi

et al. 2004

Zeitschrift Für Naturforschung C

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“…The antibacterial properties of the metal complexes and their potential for pharmacological application have been well reported [4][5][6]9,11,15]. The nickel-tetraaza complex has also been found to catalyse the division of DNA molecules [1].…”

Section: Introductionmentioning

confidence: 99%

Complexation of 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-7,14-diene dithiocyanate with nickel (II) acetate

Ishak

Yamin²

2013

AIP Conference Proceedings

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Abstract. The complexation of nickel acetate with tetraaza involves deprotonation of protonated amine nitrogen to form neutral ligand coordinated to the nickel via the four nitrogen atom. The dication complex is paired with thiocyanate anions. The complex was characterized by elemental analysis, UV-VIS and FTIR spectroscopic method. The crystal structure of nickel complex characterized by X-Ray crystallography and adopts square planar geometry.

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“…As imidas cíclicas são compostos de natureza hidrofóbica, sendo solúveis, principalmente em acetona e dimetilsulfóxido 4,5 . [9][10][11][12][13][14] .…”

Section: -Ligantes Polipiridínicosunclassified

Sínteses de monômeros derivatizados com 3-aminopiridina contendo complexos polipiridínicos de Ru(II) do tipo cis-[RuCl2(α-diimina)] onde α-diimina: 2,2᾿-bipiridina e 1,10-fenantrolina e 5-Cl-1,10-fenantrolina

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Further studies on analgesic activity of cyclic imides

Cited by 68 publications

References 1 publication

Biological Evaluation of Some Selected Cyclic Imides: Mitochondrial Effects and in vitro Cytotoxicity

Biological Evaluation of Some Selected Cyclic Imides: Mitochondrial Effects and in vitro Cytotoxicity

Complexation of 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-7,14-diene dithiocyanate with nickel (II) acetate

Sínteses de monômeros derivatizados com 3-aminopiridina contendo complexos polipiridínicos de Ru(II) do tipo cis-[RuCl2(α-diimina)] onde α-diimina: 2,2᾿-bipiridina e 1,10-fenantrolina e 5-Cl-1,10-fenantrolina

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