Further Studies of Viosterol in the Prophylaxis of Rickets in Premature Infants

Davidson, Leonard T.

doi:10.1001/archpedi.1936.01970150098008

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Calciferol in one study was classified as a vitamin D2 preparation . One drop of 250 D (vitamin D potency was expressed in D units) was equivalent to 250 IU . When a range of dietary doses was supplemented, the average of the lowest and highest doses was calculated.…”

Section: Methodsmentioning

confidence: 99%

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Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis

2012

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Vitamin D has been used to prevent and treat dental caries. The objective of this study was to conduct a systematic review of controlled clinical trials (CCTs) assessing the impact of vitamin D on dental caries prevention. Random-effects and meta-regression models were used to evaluate overall and subgroup-specific relative-rate estimates. Twenty-four CCTs encompassing 2,827 children met the inclusion criteria. Twenty-two of the 24 CCTs predated modern clinical trial design, some of which nonetheless reported characteristics such as pseudo-randomization (n = 2), blinding (n = 4), or use of placebos (n = 8). The relative-rate estimates of the 24 CCTs exhibited significant heterogeneity (P < 0.0001), and there was evidence of significant publication bias (P < 0.001). The pooled relative-rate estimate of supplemental vitamin D was 0.53 (95% CI, 0.43-0.65). No robust differences were identified between the caries-preventive effects of vitamin D(2) , vitamin D(3) , and ultraviolet radiation (Prob > F = 0.22). The analysis of CCT data identified vitamin D as a promising caries-preventive agent, leading to a low-certainty conclusion that vitamin D may reduce the incidence of caries.

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Section: Methodsmentioning

confidence: 99%

“…20 One drop of 250 D (vitamin D potency was expressed in D units) was equivalent to 250 IU. 21,22 When a range of dietary doses was supplemented, the average of the lowest and highest doses was calculated. The control intervention most closely approximating a placebo was selected for estimating vitamin D efficacy.…”

Section: Data Itemsmentioning

confidence: 99%

Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis

2012

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“…The caloric requirement, he stated, varies " from 130-120-110 calories per kilo of body weight, diminishing with the increasing weight and age of the child." Feedings should be at 2 hour intervals or even shorter ones-10 to 20 feedings in 24 hours. Gavage, or else feeding by means of a pointed spoon, must be employed in feeding very small infants.…”

mentioning

confidence: 99%

The Care of Premature Infants

Dunham¹

1939

Am J Public Health Nations Health

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Use of Percomorph Liver Oil as an Antirachitic Agent

Roddy¹,

Rose²,

Hodes³

et al. 1938

Arch Pediatr Adolesc Med

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The purpose of the study to be reported was to determine the value of percomorph liver oil1 as the sole antirachitic agent in healthy young infants, ultimate reliance being placed on roentgenologic rather than clinical criteria for detecting rickets.There has been considerable confusion concerning adequate prophylactic dosage of vitamin D, especially of the concentrates, such as viosterol. Studies in which unassayed vitamin D products and clinical rather than roentgenologic data have been used have clouded the issue.Shelling and Hopper2 have pointed out the inadequacies of the early studies in which cod liver oil and viosterol were used in the prevention of rickets. There has been much controversy over the relative

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Further Studies of Viosterol in the Prophylaxis of Rickets in Premature Infants

Cited by 4 publications

References 11 publications

Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis

Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis

The Care of Premature Infants

Use of Percomorph Liver Oil as an Antirachitic Agent

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