This paper focuses on the problem of global output feedback stabilization for a class of nonlinear cascade systems with timevarying output function. By using double-domination approach, an output feedback controller is developed to guarantee the global asymptotic stability of closed-loop system. The novel control strategy successfully constructs a unified Lyapunov function, which is suitable for both upper-triangular and lower-triangular systems. Finally, two numerical examples are provided to illustrate the effectiveness of a control strategy.