Further Observations on the Relationship of Wheat Gluten to Cœliac Disease [Summary]

Jejunal mucosal appearances after total gastrectomy

“…more distally. However it may be relevant that Anderson, Townley, Messer, and Hubbard (1962) have found mucosal changes similar to those seen in coeliac disease when the small bowel has been exposed to chronic irritants or to some abnormal condition such as ileostomy or implantation of ureters in an ileal conduit. It may be, therefore, that the abnormal circumstances produced by the oesophago-jejunal anastomosis account for the mucosal atrophy seen in this patient and possibly also for the minor changes seen in some other cases, and that the presence or absence of these changes depends simply on the distance beyond the anastomosis at which the biopsy is taken.…”