Further observations on the clinical significance and inheritance of the low‐frequency platelet antigen HPA‐28bw

Abstract

Study of this family has provided a unique opportunity to assess the clinical significance of antibodies against the low-frequency PLT antigen (HPA-28bw) during five pregnancies and to compare the outcomes of different antenatal treatments.

Simultaneous genotyping of human platelet alloantigen‐1 to 28bw systems by multiplex polymerase chain reaction sequence‐based typing

“…To date, 35 human platelet alloantigens (HPAs) have been officially nominated by the Platelet Nomenclature Committee . They have been identified on six functionally important platelet glycoprotein (GP) complexes, which were classified into 29 HPA systems (http://www.ebi.ac.uk/ipd/hpa/).…”

Serological and molecular typing in platelet alloantibody investigations

“…The human platelet antigens (HPAs) are formed due to genetic allovariants of glycoproteins on the platelet surfacethese glycoproteins are often crucial for platelet function by being receptors for extracellular matrix proteins and coagulation factors. To date, there are a total of 42 HPA antigens designated in 35 systems (HPA-1 to -35) that may cause alloimmune complications [6][7][8][9][10][11][12][13]. A link to an updated database with antigen and population frequency data is expected to be available at the ISBT Platelet Immunology Working Party homepage during 2019.…”