Further Observations on the Antimalarial Activity of CI-501 (Camolar®) against the Chesson Strain of Vivax Malaria

Gr, Coatney; Pg, Contacos; Js, Lunn

doi:10.4269/ajtmh.1964.13.383

Cited by 20 publications

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“…Additional studies on the Chesson strain, to which eight volunteers contributed, showed that dosage with CGT-P provided full protection against challenges with trophozoites and effected prompt clearance of parasitemia in volunteers with established sporozoite-induced infections (12,13). These results, together with those of the duration-of-protection study summarized above, suggested that CGT-P would be useful in both prophylactic and therapeutic settings.…”

Section: Discussionsupporting

confidence: 50%

Activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with Plasmodium cynomolgi in rhesus monkeys

Schmidt¹,

Rossan²

1984

Antimicrob Agents Chemother

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The studies summarized in this report were concerned with the capacities of repository preparations of cycloguanil pamoate (CGT-P) to protect rhesus monkeys against infections with drug-susceptible and pyrimethamine-resistant strains of Plasmodium cynomolgi. Administered The studies recorded in this report were initiated in 1961 and completed in 1966. They constituted the central part of a collaborative effort aimed at meeting the need (4) for a longlasting antimalarial drug that could be used in consort with residual insecticides in malaria eradication programs (65). This effort was catalyzed by the late Paul Thompson of the Research Division, Parke, Davis & Co., Ann Arbor, Mich., and rested on the results of his studies on the activities of repository preparations of cycloguanil pamoate (CGT-P) (the pamoic acid salt of the triazine metabolite of chlorguanide [CGT]), 4,4'-diacetyldiaminodiphenylsulfone (DADDS), and combinations of CGT-P and DADDS against infections with trophozoites of Plasmodium berghei in mice and Plasmodium cynomolgi in monkeys (60, 61). Our studies, employing infections with sporozoites of various strains of P. cynomolgi in rhesus monkeys as the primary experimental tool, dealt in sequence with (i) the capacity of CGT-P to provide longterm protection against infections with' drug-susceptible strains of this plasmodium and with the major determinants of that capacity; (ii) measurements of the release of CGT from the muscle depot of CGT-P and how the dynamics of this release affected the duration of protection; (iii) the impacts of preexisting resistance to pyrimethamine on protection accorded by. CGT-P; and (iv) the capacity of * Corresponding author. t Contribution no.

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Section: Discussionsupporting

confidence: 50%