Further observations on patients with malignant carcinoid

Abnormal forearm vascular responses in the carcinoid syndrome: the role of kinisns and kinin-generating system.

“…At least 20 minutes was permitted to elapse between studies to allow the return of the basal state. After the redetermination of control values, the vascular effects of epinephrine,2 5 ,ug 1 Obtained from Sandoz Pharmaceuticals, Hanover, N. J. The chemical and biologic identity between natural and synthetic bradykinin has been established (25).…”

“…Although the overproduction of serotonin remains the hallmark of the carcinoid syndrome (1)(2)(3), recently attention has been focused on other biologically active substances elaborated by carcinoid tumors (3)(4)(5). A variety of clinical and pathologic features distinct from those ordinarily associated with the ileal carcinoid tumor have been described, and the importance attributed to serotonin as the sole mediator of the symptoms has been challenged (3)(4)(5)(6)(7)(8).…”

Release of 5-hydroxytryptamine from blood platelets

“…It is also without effect in vitro on the intra-platelet content of potassium and causes no change in the protein content or packed volume of platelets (Paasonen, 1964;Paasonen & Solatunturi, 1965). In man, about 1 mg/day is sufficient to maintain platelet ~-H T depletion (Sjoerdsma, Weissbach, Terry & Udenfriend, 1957).…”

The histogenesis of carcinoid tumours of the rectum

“…A number of clinical syndromes have been described in association with islet-cell tumours which do not release insulin, e.g., peptic ulceration of the small intestine (Zollinger and Ellison, 1955), malabsorption syndrome (Maynard and Point, 1958), and diarrhoea and potassium depletion (Verner and Morrison, 1958;Parkins, 1961). An increased histamine excretion has been noted in some cases of the carcinoid syndrome (Sjoerdsma, Weissbach, Terry, and Udenfriend, 1957) No record has been found of the carcinoid syndrome in association with malignant atypical carcinoid of the rectum. Nevertheless, the carcinoid syndrome does occur in the non-argentaffin carcinoid of the bronchus and intestine and stomach (Snow, LennardJones, Curzon, and Stacey, 1955;Duncan, Garven, and Gibbons, 1955).…”