1956
DOI: 10.3181/00379727-92-22529
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Further Observations on Distribution of Radioactivity Following Parenteral Administration of Co60 Vitamin B12.

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Cited by 7 publications
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“…Several studies Willigan etal., 1958;Hall, 1964) have shown that the excretion of labelled vitamin B12 into bile, and the loss from the body in both faeces and urine, is relatively high during the first few days after administration. Radioactivity in the liver, in contrast to that in many other tissues, increases during this period to reach a maximum after several days to more than a week in different species (Glass et al, 1954(Glass et al, , 1955Booth & Mollin, 1956;Meyer et al, 1956;Grasbeck et al, 1961). The liver, and to a lesser degree the heart, were the only organs whose radioactive content was higher in the late period after isotope administration.…”
Section: Discussionmentioning
confidence: 92%
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“…Several studies Willigan etal., 1958;Hall, 1964) have shown that the excretion of labelled vitamin B12 into bile, and the loss from the body in both faeces and urine, is relatively high during the first few days after administration. Radioactivity in the liver, in contrast to that in many other tissues, increases during this period to reach a maximum after several days to more than a week in different species (Glass et al, 1954(Glass et al, , 1955Booth & Mollin, 1956;Meyer et al, 1956;Grasbeck et al, 1961). The liver, and to a lesser degree the heart, were the only organs whose radioactive content was higher in the late period after isotope administration.…”
Section: Discussionmentioning
confidence: 92%
“…Despite the rapid decrease of total body radioactivity observed in the early period, the liver continues to take up radioactive vitamin B12, and a period of several days to more than a week elapses before maximum values of hepatic radioactivity are obtained (Glass, Boyd, Gellin & Stephanson, 1954;Glass, Boyd & Gellin, 1955;Booth & Mollin, 1956;Meyer, Arkun & Jiminez-Casado, 1956). The dynamic characteristics of hepatic vitamin B, release are relevant to studies of vitamin B I Z metabolism which depend upon measurement of radioactivity in liver, blood and urine over short intervals of time after the administration of radioactive cyanocobalamin.…”
Section: Introductionmentioning
confidence: 97%