Further Observations in Lean and Obese Women with Gestational Diabetes During a 400-Kilocalorie Meal Tolerance Test

Hollingsworth, Dorothy R.; Ney, Denise M.; Fujimoto, Victor Y.; Milewski, Mary; Murphy, H.

doi:10.1007/978-1-4471-1680-6_22

Cited by 4 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reported success of dietary treatment alone varies in the literature. Hollingsworth et al (20) reported that 31 of 83 (37%) women with GDM required insulin in addition to a 1700-to 1800-kcal • day" 1 controlled diet. In our study, with greater calorie restriction, only 8 of the 43 (18%) women with GDM diagnosed during the study required insulin in addition to diet.…”

Section: Discussionmentioning

confidence: 98%

Calorie Restriction for Treatment of Gestational Diabetes

et al. 1991

View full text Add to dashboard Cite

Birth weights of infants of 35 gestational diabetic mothers treated with calorie restriction alone (1200-1800 kcal) were compared with those of infants of 2337 nondiabetic women, including two control groups (A and B) matched for race, body mass index, age, and parity. All women were screened for gestational diabetes with the O'Sullivan screening method, and a 3-h oral glucose tolerance test was performed on all abnormal results. Control group A mothers had a normal screen, and control group B mothers had an abnormal screen with a normal glucose tolerance test. Pregnancy weight gain was significantly less for the gestational diabetic mothers (mean +/- SD 4.6 +/- 4.9 kg) than for the general prenatal population (9.3 +/- 5.3 kg), group A control subjects (9.7 +/- 5.3 kg), and group B control subjects (9.7 +/- 5.4 kg; P less than 0.0005). No infant of a gestational diabetic mother was below the 10th percentile for weight, and birth weights were similar to those of the control groups even though weight gain after the 28th wk of gestation was only 1.7 +/- 1.6 kg. The frequency of macrosomia (birth weight greater than or equal to 4000 g) was similar among the gestational diabetic mothers (9.3%), the general prenatal population (7.4%), and group A mothers (11.6%) but significantly higher for the group B control subjects (20.9%; chi 2 = 8.57, P less than 0.005). This study demonstrated that gestational diabetic mothers who are calorie restricted have infants with normal birth weights and a frequency of macrosomia less than that of screen-positive nondiabetic women with similar macrosomic risk factors.

show abstract

Section: Discussionmentioning

confidence: 98%

Calorie Restriction for Treatment of Gestational Diabetes

et al. 1991

View full text Add to dashboard Cite

show abstract

“…We selected pregnant women matched for age, weight (BMI) and weight gain during pregnancy, who were at the peak of insulin resistance in pregnancy (28-32 weeks). Matching the subjects for parameters such as BMI appears to be important for the evaluation of glucagon levels as it has been reported that obese women with GDM (BMI 130 kg/m 2 ) have significantly higher glucagon levels in comparison with lean women with GDM (BMI !25 kg/m 2 ) and obese normal women [15]. We have further shown that non-obese women with GDM also have higher glucagon levels.…”

Section: Discussionmentioning

confidence: 57%

Hormonal Parameters in Gestational Diabetes mellitus during the Third Trimester: High Glucagon Levels

Grigorakis

Alevizaki

Beis

et al. 2000

Gynecol Obstet Invest

View full text Add to dashboard Cite

Hormonal parameters during the last trimester of pregnancy contribute to a natural increase of insulin resistance. It is not known whether any of these are further involved in the manifestation of gestational diabetes mellitus (GDM) in affected individuals. Basal levels of adrenocorticotropic hormone, cortisol, growth hormone, insulin-like growth factor-I, prolactin, glucagon, estradiol, progesterone, human placental lactogen and human chorionic gonadotropin were investigated in 15 nonobese women with GDM and 26 matched normal pregnant women (N). A linear discriminant analysis was performed to further compare the predictive value of the basal hormone levels. Plasma glucagon levels were significantly higher in the GDM group (p = 0.014); this difference was even higher (p = 0.007) when the number of women was increased (GDM = 33, N = 62). No significant differences were found in the levels of any of the other hormones. It is not clear whether elevated glucagon levels have any involvement in the pathogenesis of GDM or simply reflect the relative insulin deficiency of these women.

show abstract

“…7, 9 at increased risk of developing impaired glucose tolerance Previous studies have indicated that a mixed meal test and/or non-insulin-dependent (Type 2) diabetes later in represents an appropriate physiological challenge that life. 24 Still, patients included in the present study had may reveal even minor regulatory disturbances of varying severity of glucose intolerance, as indicated by maternal substrate levels 15,16 . Mixed meal testing may differences in gestational age at onset of insulin therapy be more sensitive than the oral glucose test for detecting and also the wide range of insulin requirement.…”

Section: Resultsmentioning

confidence: 77%