Further observations concerning hypofunction of the adrenals during early life

Free Blood Corticoids in the Newborn Infant1

“…Since these findings seem to validate the suggestions that certain infants suffer from transient adrenal failure and that others are unable to withstand the stress of surgery in the newborn period because of a lack of adrenal cortical hormones (3,4), the logical inference is that these infants should be treated with adrenal cortical hormones. The administration of these hormones to infants is dangerous.…”

A Form of Lipoidosis of the Adrenal Cortex in an Infant

“…The condition is not described in the standard works on endocrinology of Grollman (1936), Young (1937), Soffer (1946 and1951), Hartman and Brownell (1949), Williams (1950) or Yoffey (1952); on paediatrics of Nelson (1950); or on paediatric pathology of Potter (1952) or Morison (1952). No similar case is recorded in the bibliography of the physiology and pathology of the newborn for the period 1930-40 compiled by Antonov (1947) Recently the syndrome of neonatal cortical insufficiency has been described by numerous authors, e.g., Butler, Ross and Talbot (1939), Thelander and Cholffin (1941) and Jaudon (1948). This is associated with an adrenogenital syndrome whose histological findings are described by Allibone, Baar and Cant (1947).…”

“…Recently the syndrome of neonatal cortical insufficiency has been described by numerous authors, e.g., Butler, Ross and Talbot (1939), Thelander and Cholffin (1941) and Jaudon (1948). This is associated with an adrenogenital syndrome whose histological findings are described by Allibone, Baar and Cant (1947).…”

Some Typical Data from Cases of Pink Disease

“…I am therefore more impressed by evidence provided by the successful treatment of 12 cases of foetal shock with saline and deoxycortone acetate as reported by Berlind (1941). Jaudon's (1946aJaudon's ( , 1946b contributions provide such a mass of detail and critical evaluation of data that they deserve first consideration in a communication of this kind. He surveys the clinical and experimental field which encompasses his own extensive human studies, and considers that his own cases of hypofunction of the adrenals in the first weeks of life are due to fractional cortical disturbance only.…”