1941
DOI: 10.1001/jama.1941.02820450015004
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Further Experiences With Thiocyanates

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1942
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Cited by 62 publications
(2 citation statements)
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“…Flux et ale (1956) suggested that level of thiocyanate in the sera of animals fed clovers containing cyanogenetic glucosides was sufficient to produce goitre. Thiocyanate is known to be goitrogenic by inhibiting thyroidal accumulation of iodine (Astwood 1943;Rawson, Tannheimer, and Peacock 1944;Wolf et ale 1946;Barker, Lindberg, and Wald 1941;Brown-Grant and Gibson 1955). Todd, Wharton, and Todd (1938) described the effect of thyroidectomy in the lamb, and noted defective development of the epiphyses and adjacent shafts.…”
Section: Introductionmentioning
confidence: 99%
“…Flux et ale (1956) suggested that level of thiocyanate in the sera of animals fed clovers containing cyanogenetic glucosides was sufficient to produce goitre. Thiocyanate is known to be goitrogenic by inhibiting thyroidal accumulation of iodine (Astwood 1943;Rawson, Tannheimer, and Peacock 1944;Wolf et ale 1946;Barker, Lindberg, and Wald 1941;Brown-Grant and Gibson 1955). Todd, Wharton, and Todd (1938) described the effect of thyroidectomy in the lamb, and noted defective development of the epiphyses and adjacent shafts.…”
Section: Introductionmentioning
confidence: 99%
“…The syndrome of goitrous myxoedema due to prolonged administration of such drugs is now familiar clinically. Thus it may follow upon excessive administration of thiouracil to thyrotoxic patients, continuous treatment of hypertension with thiocyanate [Barker, Lindberg & Wald, 1941], or prolonged resorcinol apphcation to leg ulcers [Bull & Fraser, 1950]. …”
mentioning
confidence: 99%