Further Experiences With Thiocyanates

Barker, M. Herbert; Lindberg, Howard A.; Wald, Maurice H.

doi:10.1001/jama.1941.02820450015004

Cited by 62 publications

(2 citation statements)

References 9 publications

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“…Flux et ale (1956) suggested that level of thiocyanate in the sera of animals fed clovers containing cyanogenetic glucosides was sufficient to produce goitre. Thiocyanate is known to be goitrogenic by inhibiting thyroidal accumulation of iodine (Astwood 1943;Rawson, Tannheimer, and Peacock 1944;Wolf et ale 1946;Barker, Lindberg, and Wald 1941;Brown-Grant and Gibson 1955). Todd, Wharton, and Todd (1938) described the effect of thyroidectomy in the lamb, and noted defective development of the epiphyses and adjacent shafts.…”

Section: Introductionmentioning

confidence: 99%

Hypothyroidism in the Sheep

Lascelles¹,

Setchell²

1959

Aust. Jnl. Of Bio. Sci.

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The effect of the oral administration of methyl thiouracil at three dose rates to pregnant ewes has been studied. Observations were made on foetal skeletal growth and maturity, foetal and maternal thyroid iodine, plasma-protein-bound iodine (PBI), cholesterol, phospholipid, total esterified fatty acids, and calcium. A retardation of osseous growth and a significantly greater retardation of osseous maturity was found. The thyroid iodine concentration in both ewes and foetuses and the maternal total thyroid iodine in all treated groups were decreased but the foetal total thyroid iodine was reduced only in the two highest dose rates. Significant reduction in the foetal FBI was found only with the two highest dose rates and no significant changes were found in the maternal FBI concentration. Increases in all lipid fractions and a decrease in calcium concentration were found in the foetal plasma in the treated groups.

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Section: Introductionmentioning

confidence: 99%

Hypothyroidism in the Sheep

Lascelles¹,

Setchell²

1959

Aust. Jnl. Of Bio. Sci.

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“…The syndrome of goitrous myxoedema due to prolonged administration of such drugs is now familiar clinically. Thus it may follow upon excessive administration of thiouracil to thyrotoxic patients, continuous treatment of hypertension with thiocyanate [Barker, Lindberg & Wald, 1941], or prolonged resorcinol apphcation to leg ulcers [Bull & Fraser, 1950]. …”

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confidence: 99%

The Mode of Action of Antithyroid Drugs: Results With Two in Vitro Tests

Pitney¹,

Tr²

1953

J Endocrinol

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1. Two in vitro tests are described for measuring the inhibitory potency of antithyroid drugs on enzymic and non-enzymic oxidative iodination of protein; one, a milk enzymic iodination test, and the other an enzyme-free peroxide iodination test.2. Five recognized antithyroid drugs have been tested : 2-thiouracil, 2-carbethoxythio-methylglyoxaline, potassium thiocyanate, resorcinol and sulphathiazole. By means of the milk enzymic test they could be ranged in order of potency, as indicated by the molar concentrations required for 50 % inhibition. They could also be separated into different types by the speed with which they pass from minimal to maximal inhibition with rising molar concentration.3. With the enzyme-free peroxide test, thiouracil, but not resorcinol, was found to be inert; with the enzymic test, both were nearly equivalent in potency.

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Multiple Cutaneous Effects of Potassium Sulfocyanate

Hollander¹

1949

Arch Derm Syphilol

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Further Experiences With Thiocyanates

Cited by 62 publications

References 9 publications

Hypothyroidism in the Sheep

Hypothyroidism in the Sheep

The Mode of Action of Antithyroid Drugs: Results With Two in Vitro Tests

Multiple Cutaneous Effects of Potassium Sulfocyanate

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