Further Experiences With Methylated Thiobarbiturates

Abstract

IN a recent publication, Dundee, Barren and King (1960) reported that methylation of the thiobarbiturate, Inactin, produced a compound (B.I 37) which caused a prohibitively high incidence of spontaneous abnormal muscle movements. It was concluded that the drug was unsuitable for clinical use.

Case Report: Althesin in Status Epilepticus

“…Excitatory phenomena such as abnormal muscular movements and tremor may occur with thiobarbiturates, and these are more marked with methylated barbiturates, e.g. methohexitone (Barron and Dundee 1967) 1 ,00 .. 1 '---:,-".--appearing with increasing frequency with larger doses (Barron and Dundee 1961). Convulsions have been associated with methohexitone (Thornton 1970).…”